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1. (WO2018045308) STABILIZED GROUP 2 INFLUENZA HEMAGGLUTININ STEM REGION TRIMERS AND USES THEREOF
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Pub. No.: WO/2018/045308 International Application No.: PCT/US2017/049894
Publication Date: 08.03.2018 International Filing Date: 01.09.2017
IPC:
A61K 39/12 (2006.01) ,A61K 39/145 (2006.01) ,C07K 14/005 (2006.01) ,C07K 14/195 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
Applicants:
THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES [US/US]; Office Of Technology Transfer, National Institute Of Health 6011 Executive Blvd., Suite 325, Msc 7660 Bethesda, MD 20892-7660, US
Inventors:
BOYINGTON, Jeffrey, C.; US
GRAHAM, Barney, S.; US
MASCOLA, John, R.; US
YASSINE, Hadi, M.; QA
CORBETT, Kizzmekia, S.; US
MOIN, Syed, M.; US
WANG, Lingshu; US
KANEKIYO, Masaru; US
Agent:
STERN, Richard, J.; US
Priority Data:
62/383,26702.09.2016US
Title (EN) STABILIZED GROUP 2 INFLUENZA HEMAGGLUTININ STEM REGION TRIMERS AND USES THEREOF
(FR) TRIMÈRES À RÉGION TIGE STABILISÉE DE L'HÉMAGGLUTININE DU VIRUS DE LA GRIPPE DU GROUPE 2 ET LEURS UTILISATIONS
Abstract:
(EN) Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
(FR) L'invention concerne des vaccins induisant des anticorps contre le virus de la grippe à large spectre de protection. Ces vaccins comportent des nanoparticules qui présentent en surface des trimères d'hémagglutinine (HA) provenant du virus de la grippe du groupe 2. Les nanoparticules sont des protéines de fusion comprenant une sous-unité monomère (par exemple la ferritine) associée à des régions tiges stabilisées de protéines HA du virus de la grippe du groupe 2. Les protéines de fusion s'auto-assemblent pour former les nanoparticules présentant la HA. L'invention concerne également des protéines de fusion et des molécules d'acide nucléique codant pour de telles protéines, ainsi que des dosages faisant intervenir les nanoparticules de l'invention pour détecter des anticorps contre le virus de la grippe.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)