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1. (WO2018045276) FUSED BICYCLIC SGC STIMULATORS
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Pub. No.: WO/2018/045276 International Application No.: PCT/US2017/049834
Publication Date: 08.03.2018 International Filing Date: 01.09.2017
IPC:
C07D 487/04 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/4985 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
IRONWOOD PHARMACEUTICALS, INC. [US/US]; 301 Binney Street Cambridge, MA 02142, US
Inventors:
RENNIE, Glen Robert; US
IYENGAR, Rajesh R.; US
LEE, Thomas Wai-Ho; US
NAKAI, Takashi; US
MERMERIAN, Ara; US
JIA, Lei; US
IM, G-Yoon Jamie; US
RENHOWE, Paul Allan; US
JUNG, Joon; US
GERMANO, Peter; US
IYER, Karthik; US
BARDEN, Timothy Claude; US
TANG, Kim; US
Agent:
DAVIS, Steven G.; US
DAVIS, Steven, G.; US
BARNES, Rebecca, N.; US
BELT, Erik, P.; US
BAI, Mei; US
Priority Data:
62/382,94202.09.2016US
62/423,44517.11.2016US
62/468,59808.03.2017US
62/482,48606.04.2017US
Title (EN) FUSED BICYCLIC SGC STIMULATORS
(FR) STIMULATEURS SGC BICYCLIQUES FUSIONNÉS
Abstract:
(EN) The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula (I).
(FR) La présente invention concerne des stimulateurs de guanylate cyclase soluble (sGC), des formulations pharmaceutiques les comprenant et leurs utilisations, seuls ou en combinaison avec un ou plusieurs agents supplémentaires, pour le traitement de diverses maladies, une augmentation de la concentration d'oxyde nitrique (NO) ou une augmentation de la concentration de Monophosphate de Guanosine cyclique (cGMP), ou les deux, ou une sur-régulation de la voie de NO étant souhaitable. Les composés sont de formule I:
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)