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1. (WO2018045249) METHODS TO ANALYZE GENETIC ALTERATIONS IN CANCER TO IDENTIFY THERAPEUTIC PEPTIDE VACCINES AND KITS THEREFORE

Pub. No.:    WO/2018/045249    International Application No.:    PCT/US2017/049773
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Fri Sep 01 01:59:59 CEST 2017
IPC: G06F 19/18
G06F 19/22
C12Q 1/68
A61K 39/00
Applicants: MEDGENOME, INC.
Inventors: CHAUDHURI, Amitabha
GUPTA, Ravi
SHAH, Priyanka
MONOHARAN, Malini
PAUL, Kiran, V.
GUPTA, Rohit
Title: METHODS TO ANALYZE GENETIC ALTERATIONS IN CANCER TO IDENTIFY THERAPEUTIC PEPTIDE VACCINES AND KITS THEREFORE
Abstract:
The invention describes a method for identifying T-cell activating neo-epitopes from all genetically altered proteins. The mutated proteins contribute to neo-epitopes after they are proteolytically degraded within antigen presenting cells, such as dendritic cells and macrophages.