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|1. (WO2018045249) METHODS TO ANALYZE GENETIC ALTERATIONS IN CANCER TO IDENTIFY THERAPEUTIC PEPTIDE VACCINES AND KITS THEREFORE|
PAUL, Kiran, V.
|Title:||METHODS TO ANALYZE GENETIC ALTERATIONS IN CANCER TO IDENTIFY THERAPEUTIC PEPTIDE VACCINES AND KITS THEREFORE|
The invention describes a method for identifying T-cell activating neo-epitopes from all genetically altered proteins. The mutated proteins contribute to neo-epitopes after they are proteolytically degraded within antigen presenting cells, such as dendritic cells and macrophages.