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1. (WO2018045204) CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY
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Pub. No.: WO/2018/045204 International Application No.: PCT/US2017/049680
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
C07H 21/00 (2006.01) ,A61K 31/7084 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7084
Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
INNATE TUMOR IMMUNITY, INC. [US/US]; Route 206 and Province Line Road Princeton, NJ 08543, US
Inventors:
GLICK, Gary; US
GHOSH, Shomir; US
ROUSH, William R.; US
OLHAVA, Edward James; US
JONES, Roger; US
Agent:
GOLIAN, Paul D.; US
Priority Data:
62/382,00031.08.2016US
62/524,31623.06.2017US
Title (EN) CYCLIC DINUCLEOTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH STING (STIMULATOR OF INTERFERON GENES) ACTIVITY
(FR) ANALOGUES DE DINUCLÉOTIDES CYCLIQUES POUR TRAITER DES ÉTATS ASSOCIÉS À L'ACTIVITÉ DE LA PIQÛRE (STIMULATEUR DES GÈNES DE L'INTERFÉRON)
Abstract:
(EN) This disclosure features chemical entities (e.g., a compound that modulates (e.g., agonizes or partially agonizes) Stimulator of Interferon Genes (STING), or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that are useful, e.g., for treating a condition, disease or disorder in which a decrease or increase in STING activity (e.g., a decrease, e.g., a condition, disease or disorder associated with repressed or impaired STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.
(FR) La présente invention concerne des entités chimiques (par exemple, un composé qui module (par exemple, agonistes ou agonistes partiels) Stimulateur de gènes d’interféron (STING), ou un sel pharmaceutiquement acceptable, et/ou un hydrate, et/ou un co-cristal, et/ou une combinaison de médicament du composé) qui sont utiles, par exemple, pour traiter une affection, une maladie ou un trouble où une diminution ou une augmentation de l'activité de STING (par exemple, une diminution, par exemple, une affection, une maladie ou un trouble associé à une signalisation STING réprimée ou altérée) contribue à la pathologie et/ou aux symptômes et/ou à l'évolution de l'affection, de la maladie ou du trouble (par exemple, cancer) chez un sujet (par exemple, sujet humain). L'invention concerne également des compositions ainsi que d'autres procédés d'utilisation et de fabrication desdites compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)