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1. (WO2018045200) ENGINEERED SUBTILIGASE VARIANTS FOR VERSATILE, SITE-SPECIFIC LABELING OF PROTEINS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/045200    International Application No.:    PCT/US2017/049670
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
C07K 1/02 (2006.01), C07K 1/36 (2006.01), C07K 14/32 (2006.01)
Applicants: THE REGENT OF THE UNIVERSITY OFCALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor Oakland, CA 94607-5200 (US)
Inventors: WELLS, James, A.; (US).
WEEKS, Amy, M.; (US)
Agent: MANN, Jeffry, S.; (US).
MA, Kun; (US).
LOVEJOY, Brett, A.; (US).
MANN, Jeffry, S.; (US).
ESKER, Todd, W.; (US)
Priority Data:
62/547,496 18.08.2017 US
62/398,898 23.09.2016 US
62/383,265 02.09.2016 US
Title (EN) ENGINEERED SUBTILIGASE VARIANTS FOR VERSATILE, SITE-SPECIFIC LABELING OF PROTEINS
(FR) VARIANTS DE SUBTILIGASE MODIFIÉS POUR L'ÉTIQUETAGE POLYVALENT, SPÉCIFIQUE DE SITE DE PROTÉINES
Abstract: front page image
(EN)In various embodiments, the invention provides subtiligase variants that recognize an N- terminus of a protein or peptide substrate that is different than the N-terminus that is recognized by the corresponding wild-type subtiligase. Also provided are methods and kits for using such subtiligase variants to site-specifically ligate a synthetic molecule comprising a peptide ester to a protein or peptide substrate of interest.
(FR)Selon divers modes de réalisation, l'invention concerne des variants de subtiligase qui reconnaissent une extrémité N-terminale d'un substrat de protéine ou de peptide qui est différent de l'extrémité N-terminale qui est reconnue par la subtiligase de type sauvage correspondante. L'invention concerne également des procédés et des trousses pour utiliser de tels variants de la subtiligase pour une ligature spécifique de site d'une molécule synthétique comprenant un ester peptidique à un substrat de protéine ou de peptide d'intérêt.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)