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1. (WO2018045184) ENGINEERED BACTERIA SECRETING THERAPEUTIC PROTEINS AND METHODS OF USE THEREOF
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Pub. No.: WO/2018/045184 International Application No.: PCT/US2017/049639
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
A61K 35/74 (2015.01) ,C07K 14/195 (2006.01) ,C07K 14/245 (2006.01) ,C07K 19/00 (2006.01)
[IPC code unknown for A61K 35/74][IPC code unknown for C07K 14/195][IPC code unknown for C07K 14/245][IPC code unknown for C07K 19]
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138, US
Inventors:
NGUYEN, Peter, Q.; US
JOSHI, Neel, Satish; US
Agent:
ZACHARAKIS, Maria, Laccotripe; US
BLAZESKI, George; US
BELT, Erik, P.; US
BARNES, Rebecca, N.; US
BAI, Mei; US
Priority Data:
62/381,96131.08.2016US
Title (EN) ENGINEERED BACTERIA SECRETING THERAPEUTIC PROTEINS AND METHODS OF USE THEREOF
(FR) BACTÉRIES GÉNÉTIQUEMENT MODIFIÉES SÉCRÉTANT DES PROTÉINES THÉRAPEUTIQUES ET PROCÉDÉS D'UTILISATION DE CELLES-CI
Abstract:
(EN) Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.
(FR) L'invention concerne des bactéries génétiquement modifiées qui sécrètent des polypeptides thérapeutiques, des compositions pharmaceutiques comprenant les bactéries, des procédés de production de polypeptides recombinés, et des procédés d'utilisation des bactéries à des fins diagnostiques et thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)