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1. (WO2018045157) PROCESS FOR PREPARING INDOLE CARBOXAMIDE COMPOUNDS

Pub. No.:    WO/2018/045157    International Application No.:    PCT/US2017/049589
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Fri Sep 01 01:59:59 CEST 2017
IPC: C07D 401/04
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: FAN, Junying
GENG, Peng
STROTMAN, Neil A.
BOROVIKA, Alina
STEVENS, Jason Michael
SKLIAR, Dimitri
Title: PROCESS FOR PREPARING INDOLE CARBOXAMIDE COMPOUNDS
Abstract:
Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-lH-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7- carboxamide.