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1. (WO2018045141) ANALYSIS OF CHROMATIN USING A NICKING ENZYME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/045141    International Application No.:    PCT/US2017/049556
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
C12Q 1/68 (2018.01)
Applicants: NEW ENGLAND BIOLABS, INC. [US/US]; 240 County Road Ipswich, MA 01938 (US)
Inventors: PONNALURI, Chaithanya; (US).
CHIN, Hang-Gyeong; (US).
ESTEVE, Pierre, Olivier; (US).
PRADHAN, Sriharsa; (US)
Agent: STRIMPEL, Harriet, M.; (US)
Priority Data:
62/383,151 02.09.2016 US
Title (EN) ANALYSIS OF CHROMATIN USING A NICKING ENZYME
(FR) ANALYSE DE LA CHROMATINE AU MOYEN D'UNE ENZYME DE COUPURE
Abstract: front page image
(EN)Provided herein, among other things, are various compositions and methods for analyzing chromatin. In some embodiments, the composition may comprise a mixture of a nicking enzyme, four dNTPs, at least one labeled dNTP and, optionally, a polymerase. In some embodiments, this method may comprise: obtaining a sample comprising chromatin, reacting the sample with the composition to selectively label the open chromatin in the sample, and analyzing the labeled sample.
(FR)L'invention concerne, entre autres, diverses compositions et divers procédés d'analyse de la chromatine. Dans certains modes de réalisation, la composition peut comprendre un mélange d'une enzyme de coupure, de quatre dNTP, d'au moins un dNTP marqué et, éventuellement, d'une polymérase. Dans certains modes de réalisation, ce procédé peut consister à obtenir un échantillon comprenant de la chromatine, à faire réagir l'échantillon avec la composition pour marquer sélectivement la chromatine ouverte dans l'échantillon, et à analyser l'échantillon marqué.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)