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1. (WO2018045071) INHIBITORS OF CELLULAR METABOLIC PROCESSES

Pub. No.:    WO/2018/045071    International Application No.:    PCT/US2017/049439
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Aug 31 01:59:59 CEST 2017
IPC: C07D 487/04
C07F 9/141
A61K 31/519
A61P 35/00
Applicants: AGIOS PHARMACEUTICALS, INC.
KONTEATIS, Zenon D.
SUI, Zhihua
TRAVINS, Jeremy M.
YE, Zhixiong
Inventors: KONTEATIS, Zenon D.
SUI, Zhihua
TRAVINS, Jeremy M.
YE, Zhixiong
Title: INHIBITORS OF CELLULAR METABOLIC PROCESSES
Abstract:
The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA), wherein RA, RB, RC, RD, and RE are defined herein.