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1. (WO2018045034) CHIMERIC ANTIGEN RECEPTORS HAVING GITR INTRACELLULAR DOMAIN AS CO-STIMULATORY DOMAIN

Pub. No.:    WO/2018/045034    International Application No.:    PCT/US2017/049385
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Aug 31 01:59:59 CEST 2017
IPC: A61K 35/17
C07K 16/28
C07K 19/00
C12N 15/62
Applicants: PROMAB BIOTECHNOLOGIES, INC.
FOREVERTEK BIOTECHNOLOGY CO., LTD
THE GENERAL HOSPITAL CORPORATION
Inventors: WU, Lijun
MAUS, Marcela V.
GOLUBOVSKAYA, Vita
Title: CHIMERIC ANTIGEN RECEPTORS HAVING GITR INTRACELLULAR DOMAIN AS CO-STIMULATORY DOMAIN
Abstract:
The present invention is directed to a chimeric antigen receptor (CAR) fusion protein comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) comprising VH and VL, wherein scFv binds to a tumor antigen, (ii) a transmembrane domain, (iii) a co- stimulatory domain of GITR intracellular domain, and (iv) an activating domain. In one embodiment, the tumor antigen is human epidermal growth factor receptor (EGFR), human mesothelin, or human CD19. CARs having GITR intracellular domain as a co- stimulatory domain have certain advantages over other traditional CAR co-stimulatory domains.