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1. (WO2018045018) PRODUCTION OF SELENO-BIOLOGICS IN GENOMICALLY RECODED ORGANISMS

Pub. No.:    WO/2018/045018    International Application No.:    PCT/US2017/049354
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Aug 31 01:59:59 CEST 2017
IPC: A61K 39/395
A61K 38/28
C12P 21/02
C12P 21/08
C12N 15/09
C12N 15/10
C12N 15/11
G06F 19/16
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
GREGG, Christopher, J.
Inventors: GREGG, Christopher, J.
MANDELL, Daniel, J.
THYER, Ross
ELLINGTON, Andrew, D.
STRANGES, Peter Benjamin
Title: PRODUCTION OF SELENO-BIOLOGICS IN GENOMICALLY RECODED ORGANISMS
Abstract:
Polypeptides that fold into biologies are stabilized by diselenide bonds between selenocysteine amino acids. Methods to produce such polypeptides in genomically recoded organisms (GRO) can be scaled up for industrial production. Since diselenides have the same geometric bond angles and torsions as disulfides, as well as very similar bond lengths, they can be substituted into polypeptides without disrupting the three dimensional structure of the polypeptides. Diselenides render the polypeptides resistant to reduction when they are exposed to blood serum or to reducing components of blood serum or to reducing components components within cells.