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1. (WO2018044986) TRIAZINOINDOLE-BASED CHEMICAL INHIBITORS OF EUKARYOTIC RIBOSOME BIOGENESIS
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Pub. No.: WO/2018/044986 International Application No.: PCT/US2017/049295
Publication Date: 08.03.2018 International Filing Date: 30.08.2017
IPC:
A61K 31/404 (2006.01) ,C07D 209/04 (2006.01) ,C07D 487/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
THE ROCKEFELLER UNIVERSITY [US/US]; Office of Technology Transfer 1230 York Avenue New York, New York 10065-6399, US
Inventors:
KAPOOR, Tarun M.; US
Agent:
HANSEN, Philip E.; US
Priority Data:
62/381,35530.08.2016US
62/382,59701.09.2016US
62/410,60520.10.2016US
Title (EN) TRIAZINOINDOLE-BASED CHEMICAL INHIBITORS OF EUKARYOTIC RIBOSOME BIOGENESIS
(FR) INHIBITEURS CHIMIQUES DE BIOGENÈSE DE RIBOSOMES EUCARYOTES À BASE DE TRIAZINOINDOLE
Abstract:
(EN) Triazinoindole-based chemical inhibitors of eukaryotic ribosome genesis are disclosed. The compounds have the following structure: The compounds disclosed are useful in treatment of fungal disease and similar diseases associated with the dysregulation of the midasin signaling pathway.
(FR) L'invention concerne des inhibiteurs chimiques de la genèse des ribosomes eucaryotes à base de Triazinoindole. Les composés ont la structure suivante : les composés décrits sont utiles dans le traitement d'une maladie fongique et de maladies similaires associées à la dysrégulation de la voie de signalisation de de midasin.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)