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1. (WO2018044940) COMPOSITIONS AND METHODS FOR TREATING A TUMOR SUPPRESSOR DEFICIENT CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/044940    International Application No.:    PCT/US2017/049200
Publication Date: 08.03.2018 International Filing Date: 29.08.2017
IPC:
C12N 5/00 (2006.01), G01N 33/574 (2006.01), G01N 33/68 (2006.01)
Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER [US/US]; 330 Brookline Avenue Boston, Massachusetts 02215 (US)
Inventors: PANDOLFI, Pier Paolo; (US)
Agent: HUNTER-ENSOR, PH.D., Melissa; (US)
Priority Data:
62/381,246 30.08.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING A TUMOR SUPPRESSOR DEFICIENT CANCER
(FR) COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UN CANCER DÉFICIENT EN SUPPRESSEUR DE TUMEUR
Abstract: front page image
(EN)As described below, the present invention features compositions and methods of treating cancers characterized by the loss of Pten, Zbtb7a/Pokemon, p53, Pml and other tumor suppressors by inhibiting the expression or activity of CXCL5; and methods for identifying therapeutics using a murine platform.
(FR)L'invention concerne, ainsi qu'il est décrit ci-dessous, des compositions et des méthodes de traitement de cancers caractérisés par la perte de Pten, Zbtb7a/Pokemon, p53, Pml et d'autres suppresseurs de tumeurs, par inhibition de l'expression ou de l'activité de CXCL5; et des méthodes d'identification de thérapeutiques utilisant une plateforme murine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)