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1. (WO2018044809) COMPOSITIONS AND METHODS FOR REPROGRAMMING ADULT CELLS THROUGH THE STEMNESS OF A PLATELET RICH FRACTION OF BLOOD CONTAINING PLATELET-LIKE CELLS IN HUMANS

Pub. No.:    WO/2018/044809    International Application No.:    PCT/US2017/048945
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Tue Aug 29 01:59:59 CEST 2017
IPC: A61K 38/17
A61K 48/00
C07K 14/47
C12N 5/078
C12N 5/0781
C12N 5/0783
C12N 5/0786
C12N 15/09
C12N 15/87
Applicants: HACKENSACK UNIVERSITY MEDICAL CENTER
Inventors: ZHAO, Yong
Title: COMPOSITIONS AND METHODS FOR REPROGRAMMING ADULT CELLS THROUGH THE STEMNESS OF A PLATELET RICH FRACTION OF BLOOD CONTAINING PLATELET-LIKE CELLS IN HUMANS
Abstract:
The described invention provides a method of functionally reprogramming adult cells to an immature cell type that expresses one or more embryonic biomarkers with a platelet rich fraction comprising platelet-like cells from umbilical cord blood or peripheral blood, and expanding the immature cell type in vitro under culture conditions to generate an insulin-producing cell population that expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells. It further provides a pharmaceutical composition comprising a cell product containing a therapeutic amount of an insulin-producing cell population, wherein the insulin-producing cell population expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells, and a method for treating a recipient subject suffering from a disease characterized by hyperglycemia with the pharmaceutical composition.