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1. (WO2018044778) METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS

Pub. No.:    WO/2018/044778    International Application No.:    PCT/US2017/048872
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Tue Aug 29 01:59:59 CEST 2017
IPC: A61K 38/00
A61P 1/16
A61P 3/00
C07K 14/50
Applicants: NGM BIOPHARMACEUTICALS, INC
Inventors: LING, Lei
TIAN, Hui
Title: METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS
Abstract:
Provided herein are variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). In some embodiments, these variants and fusions modulate bile acid homeostasis, and are useful in treatment of bile acid related and associated disorders. In some embodiments, these variants and fusions have glucose lowering activity, and are useful in treatment of hyperglycemia and other disorders.