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1. (WO2018044767) AMINOPYRIMIDINES AS ALK INHIBITORS

Pub. No.:    WO/2018/044767    International Application No.:    PCT/US2017/048845
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Tue Aug 29 01:59:59 CEST 2017
IPC: C07D 405/14
C07D 401/12
A61K 31/506
A61P 35/00
A61P 29/00
A61P 37/00
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: WANG, Shaomeng
CHEN, Jianyong
Title: AMINOPYRIMIDINES AS ALK INHIBITORS
Abstract:
The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, and R7 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to inhibition of ALK such as cancer.