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1. (WO2018044662) DOSAGE REGIMEN FOR TREATMENT OF SOLID TUMORS

Pub. No.:    WO/2018/044662    International Application No.:    PCT/US2017/048308
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Fri Aug 25 01:59:59 CEST 2017
IPC: A61K 31/55
A61P 35/00
A61K 45/06
A61K 31/573
Applicants: ELI LILLY AND COMPANY
Inventors: BENHADJI, Karim, Adnane
YUEN, Eunice, Soek, Mun
Title: DOSAGE REGIMEN FOR TREATMENT OF SOLID TUMORS
Abstract:
A dosing regimen comprising administering 4,4,4-trifluoro-N-[(1S)-2-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-methyl-2-oxo-ethyl]butanamide or a pharmaceutically acceptable salt or hydrate thereof for treating a solid tumor cancer at a specified loading dose for a defined period of doses followed by a maintenance dose and optionally administering a corticosteroid during administration of the loading dose is provided.