Search International and National Patent Collections

1. (WO2018044356) IN-SITU SOLVENT RECYCLING PROCESS FOR SOLID PHASE PEPTIDE SYNTHESIS AT ELEVATED TEMPERATURES

Pub. No.:    WO/2018/044356    International Application No.:    PCT/US2017/028254
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Apr 20 01:59:59 CEST 2017
IPC: C07K 1/04
C07K 1/06
Applicants: CEM CORPORATION
Inventors: COLLINS, Jonathan, M.
Title: IN-SITU SOLVENT RECYCLING PROCESS FOR SOLID PHASE PEPTIDE SYNTHESIS AT ELEVATED TEMPERATURES
Abstract:
An improvement in of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated amino acid from the preceding coupling cycle; and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle; and with the coupling solution at a temperature of at least 30°C.