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1. (WO2018044242) METHOD FOR PREPARING AN EXTRACT OF HEVEA LATEX AND COMPOSITION THEREOF
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Pub. No.: WO/2018/044242 International Application No.: PCT/TH2016/000075
Publication Date: 08.03.2018 International Filing Date: 02.09.2016
Chapter 2 Demand Filed: 10.05.2018
IPC:
C08C 1/02 (2006.01) ,C08C 1/04 (2006.01) ,C08C 2/02 (2006.01) ,C08L 7/02 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
C
TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
1
Treatment of rubber latex
02
Chemical or physical treatment of rubber latex before or during concentration
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
C
TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
1
Treatment of rubber latex
02
Chemical or physical treatment of rubber latex before or during concentration
04
Purifying; Deproteinising
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
C
TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
2
Treatment of rubber solutions
02
Purification
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
7
Compositions of natural rubber
02
Latex
Applicants:
THAILAND CENTER OF EXCELLENCE FOR LIFE SCIENCES [TH/TH]; 22nd Floor, CMMU Building 69, Vibhavadi-Rangsit Road, Samsen Nai, Phayathai Bangkok 10400, TH
PRINCE OF SONGKLA UNIVERSITY [TH/TH]; 15 Karnjanavanich Road, Hat Yai Songkhla 90110, TH
Inventors:
WITITSUWANNAKUL, Rapepun; TH
YOYSUNGNOEN, Bhornprom; TH
Agent:
TANASUGARN, Lerson; P.O. Box 256 Samsennai, Phyathai Bangkok 10400, TH
Priority Data:
Title (EN) METHOD FOR PREPARING AN EXTRACT OF HEVEA LATEX AND COMPOSITION THEREOF
(FR) PROCÉDÉ DE PRÉPARATION D'UN EXTRAIT DE LATEX D'HÉVÉA ET COMPOSITION EN CONTENANT
Abstract:
(EN) The present disclosure provides for the method of preparing, from serum of calendered acidified Hevea latex, an extract that is rich in low-molecular weight carbohydrates and having anti-cancer activity. The method comprises the steps of: obtaining the serum released when acidified Hevea latex is calendered; optionally removing debris and micro-organisms from the serum; removing proteins; removing quebrachitol and small polar molecules; optionally dissolving the remaining solid powder in water; further removing proteins by treatment with acid; optionally neutralizing the excess acid; precipitating with solvent; collecting the precipitate; and optionally freeze drying the precipitate. The disclosure also provides for the method of treating cancer growth and/or metastasis and the method of inhibiting tumor cell proliferation in a patient. Furthermore, there are provided a pharmaceutical composition and a functional food composition comprising the disclosed extract of Hevea latex.
(FR) La présente invention concerne le procédé de préparation, à partir de sérum de latex d'hévéa acidifié et laminé, d'un extrait riche en glucides de faible poids moléculaire et présentant une activité anticancéreuse. Le procédé comprend les étapes consistant à obtenir le sérum libéré lorsque du latex d'hévéa acidifié est laminé; à éliminer éventuellement les débris et les micro-organismes du sérum; à éliminer les protéines; à éliminer le québrachitol et les petites molécules polaires; à dissoudre éventuellement la poudre solide restant dans l'eau; à éliminer encore des protéines par traitement avec de l'acide; éventuellement à neutraliser l'excès d'acide; à précipiter le tout avec un solvant; à recueillir le précipité; et, éventuellement, à lyophiliser le précipité. L'invention concerne également une méthode de traitement du développement d'un cancer et/ou de la métastase cancéreuse et un procédé d'inhibition de la prolifération de cellules tumorales chez un patient. En outre, l'invention concerne une composition pharmaceutique et une composition alimentaire fonctionnelle comprenant l'extrait décrit de latex d'hévéa.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)