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1. (WO2018044239) METHOD OF TREATING CANCER BY ANTISENSE OLIGONUCLEOTIDES TARGETING PRDM15

Pub. No.:    WO/2018/044239    International Application No.:    PCT/SG2017/050436
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Tue Sep 05 01:59:59 CEST 2017
IPC: A61K 31/7088
C12N 15/113
A61P 35/00
C12Q 1/68
G01N 33/68
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors: GUCCIONE, Ernesto
WEE, Keng Boon, Dave
Title: METHOD OF TREATING CANCER BY ANTISENSE OLIGONUCLEOTIDES TARGETING PRDM15
Abstract:
The present invention relates to antisense oligonucleotides for modulating the activity of PRDM15 and use thereof in the treatment of cancer. In particular, said antisense oligonucleotides are capable of inducing the skipping of an exon of a PRDM15 mRNA. The present invention also relates to a method for determining prognosis in a patient with cancer, or selecting a therapeutic strategy for a patient with cancer, by assessing the level of PRDM15 nucleic acid, protein or activity in a sample.