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1. (WO2018044234) CYSTEINE-RICH POLYPEPTIDES AND CONJUGATES AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/044234    International Application No.:    PCT/SG2017/050428
Publication Date: 08.03.2018 International Filing Date: 30.08.2017
IPC:
C07K 14/415 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: NANYANG TECHNOLOGICAL UNIVERSITY [SG/SG]; 50 Nanyang Avenue Singapore 639798 (SG)
Inventors: TAM, James P.; (SG).
KAM, Antony; (SG).
LOO, Shining; (SG)
Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O Box 1088, Rochor Post Office, Rochor Road Singapore 911833 (SG)
Priority Data:
10201607237U 31.08.2016 SG
10201607254W 31.08.2016 SG
Title (EN) CYSTEINE-RICH POLYPEPTIDES AND CONJUGATES AND METHODS OF USING THE SAME
(FR) POLYPEPTIDES ET CONJUGUES RICHES EN CYSTEINE ET PROCÉDÉS DE LEUR UTILISATION
Abstract: front page image
(EN)The present invention relates to the identification and utilization of a novel class of cystine-rich peptides, wherein the peptide comprises three disulfide bridges that form a cystine-knot structural motif. Provided are polypeptides and conjugates as defined herein as well as methods of inhibiting neutrophil elastase, methods of delivering an agent of interest to a mitochondrion of a target cell, and methods of treating or preventing a disease, disorder, or condition in a subject using said polypeptides or conjugates.
(FR)La présente invention concerne l'identification et l'utilisation d'une nouvelle classe de peptides riches en cystine, le peptide comprenant trois ponts disulfure qui forment un motif structural de nœud de cystine. L'invention concerne des polypeptides et des conjugués tels que définis dans la description, ainsi que des procédés d'inhibition de l'élastase neutrophile, des procédés d'administration d'un agent d'intérêt à une mitochondrie d'une cellule cible, et des procédés de traitement ou de prévention d'une maladie, d'un trouble ou d'un état chez un sujet à l'aide desdits polypeptides ou conjugués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)