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1. (WO2018044150) A METHOD FOR PRODUCING DEMETHYLBELAMCANDAQUINONE B FROM LABISIA PUMILA
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Pub. No.: WO/2018/044150 International Application No.: PCT/MY2017/050050
Publication Date: 08.03.2018 International Filing Date: 15.08.2017
IPC:
C07C 46/10 (2006.01) ,C07C 50/30 (2006.01) ,A61K 31/122 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
46
Preparation of quinones
10
Separation; Purification; Stabilisation; Use of additives
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
50
Quinones
26
containing groups having oxygen atoms singly bound to carbon atoms
30
with polycyclic non-condensed quinoid structure
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
Applicants:
UNIVERSITI KEBANGSAAN MALAYSIA [MY/MY]; UNIVERSITI KEBANGSAAN MALAYSIA (UKM) BANGI, SELANGOR, 43600, MY
Inventors:
BIN SHUID, Ahmad Nazrun; MY
SOELAIMAN, Ima Nirwana; MY
BIN JANTAN, Ibrahim; MY
BINTI JAMAL, Jamia Azdina; MY
BINTI MOHAMED, Norazlina; MY
BINTI MUHAMMAD, Norliza; MY
BIN NAINA MOHAMED, Isa; MY
Agent:
H A RASHID, Ahmad Fadzlee; MY
Priority Data:
PI 201670317630.08.2016MY
Title (EN) A METHOD FOR PRODUCING DEMETHYLBELAMCANDAQUINONE B FROM LABISIA PUMILA
(FR) PROCÉDÉ DE PRODUCTION DE DÉMÉTHYLBELAMCANDAQUINONE B À PARTIR DE LABISIA PUMILA
Abstract:
(EN) The present invention relates to a method for producing demethylbelamcandaquinone B from Labisia pumila and use thereof. The method is characterized by the steps of obtaining an extract from Labisia pumila plant material using water extraction, filtering the extract to obtain a filtrate, freeze drying the filtrate to obtain a freeze-dried solid, extracting the freeze-dried solid using an organic solvent to obtain a crude extract, removing the organic solvent from the crude extract to obtain a concentrated extract, chromatographically isolating demethylbelamcandaquinone B from the concentrated extract and chromatographically purifying the isolated demethylbelamcandaquinone B.
(FR) La présente invention concerne un procédé de production de déméthylbelamcandaquinone B à partir de Labisia pumila et son utilisation. Le procédé est caractérisé par les étapes consistant à obtenir un extrait d'un matériau végétal de Labisia pumila par extraction aqueuse, à filtrer l'extrait pour obtenir un filtrat, à lyophiliser le filtrat pour obtenir un solide lyophilisé, à extraire le solide lyophilisé à l'aide d'un solvant organique pour obtenir un extrait brut, à éliminer le solvant organique de l'extrait brut pour obtenir un extrait concentré, à isoler chromatographiquement la déméthylbelamcandaquinone B de l'extrait concentré et à purifier chromatographiquement la déméthylbelamcandaquinone B isolée.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)