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1. (WO2018044126) COMPLEX BIOMARKER GROUP FOR DIAGNOSIS OF LUNG CANCER IN SUBJECT, KIT FOR DIAGNOSIS OF LUNG CANCER USING SAME, METHOD FOR USING INFORMATION OF COMPLEX BIOMARKER GROUP, AND COMPUTING SYSTEM FOR CONDUCTING METHOD
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Pub. No.: WO/2018/044126 International Application No.: PCT/KR2017/009616
Publication Date: 08.03.2018 International Filing Date: 01.09.2017
IPC:
G01N 33/574 (2006.01) ,G06F 19/00 (2011.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
Applicants:
(주)바이오인프라생명과학 BIOINFRA LIFE SCIENCE INC. [KR/KR]; 서울시 종로구 대학로 49 7층 7th Fl., 49, Daehak-ro, Jongno-gu, Seoul 03127, KR
Inventors:
김철우 KIM, Chul Woo; KR
김용대 KIM, Yong Dai; KR
신용성 SHIN, Yong Sung; KR
연은희 YEON, Eun Hee; KR
강경남 KANG, Kyung Nam; KR
신호상 SHIN, Ho Sang; KR
권오란 KWON, Oh Ran; KR
Agent:
특허법인 수 SU INTELLECTUAL PROPERTY; 서울시 강남구 강남대로 94길 34, 6층 (역삼동,케이앤와이빌딩) (Yeoksam-dong, K&Y Bldg.) 6Fl., 34, Gangnam-daero 94-gil Gangnam-gu Seoul 06134, KR
Priority Data:
10-2016-011344402.09.2016KR
Title (EN) COMPLEX BIOMARKER GROUP FOR DIAGNOSIS OF LUNG CANCER IN SUBJECT, KIT FOR DIAGNOSIS OF LUNG CANCER USING SAME, METHOD FOR USING INFORMATION OF COMPLEX BIOMARKER GROUP, AND COMPUTING SYSTEM FOR CONDUCTING METHOD
(FR) GROUPE DE BIOMARQUEURS COMPLEXES PERMETTANT LE DIAGNOSTIC DU CANCER DU POUMON CHEZ UN SUJET, KIT DE DIAGNOSTIC DU CANCER DU POUMON L'UTILISANT, PROCÉDÉ D'UTILISATION D'INFORMATIONS SUR UN GROUPE DE BIOMARQUEURS COMPLEXES, ET SYSTÈME INFORMATIQUE DESTINÉ À LA MISE EN ŒUVRE DU PROCÉDÉ
(KO) 피험체의 폐암 진단을 위한 복합 바이오마커군, 이를 이용하는 폐암 진단용 키트, 복합 바이오마커군의 정보를 이용하는 방법 및 이를 수행하는 컴퓨팅 시스템
Abstract:
(EN) According to the present invention, provided is a kit for diagnosis of lung cancer, the kit comprising: a complex biomarker group for diagnosis of lung cancer, the complex biomarker group comprising individual biomarkers carcinoembryonic antigen (CEA), human epididymis protein 4 (HE4), apolipoprotein A-II (ApoA2), transthyretin (TTR), soluble vascular cell adhesion molecule-1 (sVCAM-1), and regulated on activation, normal T cell expressed and secreted/chemokine (C-C motif) ligand 5 (RANTES); and antibodies specifically binding to the individual biomarkers CEA, HE4, ApoA2, TTR, sVCAM-1, and RANTES.
(FR) La présente invention concerne un kit permettant le diagnostic du cancer du poumon comprenant : un groupe de biomarqueurs complexes destiné au diagnostic du cancer du poumon, le groupe de biomarqueurs complexes comprenant des biomarqueurs individuels de l'antigène carcino-embryonnaire (CEA), de la protéine humaine épididymal 4 (HE4), de l'apolipoprotéine a-II (ApoA2), de la transthyrétine (TTR), une molécule -1 d'adhésion cellulaire vasculaire soluble (sVCAM -1), et régulée sur l'activation, une cellule T normale exprimée et sécrétée/chimiokine (motif C-C) ligand 5 (RANTES) ; et des anticorps se liant spécifiquement aux biomarqueurs individuels CEA, HE4, ApoA2, TTR, sVCAM -1, et RANTES.
(KO) 본 발명에 따르면, 개별 바이오마커 CEA(Carcinoembryonic antigen; 암배 항원), HE4(Human Epididymis Protein 4; 인간 부고환 단백질 4), ApoA2(Apolipoprotein A-II), TTR(Transthyretin; TTR), sVCAM-1(soluble vascular cell adhesion molecule-1) 및 RANTES{regulated on activation, normal T cell expressed and secreted; Chemokine (C-C motif) ligand 5}를 포함하는 폐암 진단용 복합 바이오마커군, 개별 바이오마커 CEA, HE4, ApoA2, TTR, sVCAM-1 및 RANTES에 특이적으로 결합하는 항체들을 포함하는 폐암 진단용 키트가 제공된다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)