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|1. (WO2018043942) ORAL DOSAGE FORM OF PARATHYROID HORMONE COMPRISING GASTROINTESTINAL ABSORPTION ENHANCER|
|Applicants:||MOKPO NATIONAL UNIVERSITY INDUSTRY-ACADEMIA COOPERATION GROUP
B&L DELIPHARM, CORP.
|Inventors:||PARK, Jin Woo
JEON, Ok Cheol
|Title:||ORAL DOSAGE FORM OF PARATHYROID HORMONE COMPRISING GASTROINTESTINAL ABSORPTION ENHANCER|
The present invention provides a complex formed by mixing parathyroid hormone (PTH) or the fragment teriparatide (PTH(1-34)) thereof, which both account for an osteopromotive mechanism, and a deoxycholic acid derivative (deoxycholic acid and lysine associate), which is an intestinal membrane permeability enhancer, at a molar ratio of 1 to 10 through ion-ion interaction therebetween, and an oral dosage form of parathyroid hormone comprising a gastrointestinal absorption enhancer, which is the complex in the form of enteric coated microparticles. Therefore, the oral dosage form enhances the intestinal membrane permeability and gastrointestinal absorption of PTH and thus is effective for the treatment of osteoporosis.