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1. (WO2018043942) ORAL DOSAGE FORM OF PARATHYROID HORMONE COMPRISING GASTROINTESTINAL ABSORPTION ENHANCER

Pub. No.:    WO/2018/043942    International Application No.:    PCT/KR2017/008604
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Aug 10 01:59:59 CEST 2017
IPC: A61K 9/00
A61K 47/18
A61K 47/38
A61K 38/29
A61K 9/16
Applicants: MOKPO NATIONAL UNIVERSITY INDUSTRY-ACADEMIA COOPERATION GROUP
목포대학교산학협력단
B&L DELIPHARM, CORP.
비앤엘델리팜 주식회사
Inventors: PARK, Jin Woo
박진우
JEON, Ok Cheol
전옥철
Title: ORAL DOSAGE FORM OF PARATHYROID HORMONE COMPRISING GASTROINTESTINAL ABSORPTION ENHANCER
Abstract:
The present invention provides a complex formed by mixing parathyroid hormone (PTH) or the fragment teriparatide (PTH(1-34)) thereof, which both account for an osteopromotive mechanism, and a deoxycholic acid derivative (deoxycholic acid and lysine associate), which is an intestinal membrane permeability enhancer, at a molar ratio of 1 to 10 through ion-ion interaction therebetween, and an oral dosage form of parathyroid hormone comprising a gastrointestinal absorption enhancer, which is the complex in the form of enteric coated microparticles. Therefore, the oral dosage form enhances the intestinal membrane permeability and gastrointestinal absorption of PTH and thus is effective for the treatment of osteoporosis.