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1. (WO2018043734) ANTI-TGF-BETA 1 ANTIBODIES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/043734    International Application No.:    PCT/JP2017/031690
Publication Date: 08.03.2018 International Filing Date: 04.09.2017
IPC:
C07K 16/22 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), C07K 16/46 (2006.01), C12P 21/08 (2006.01), C12N 15/09 (2006.01)
Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 5-chome, Kita-ku, Tokyo 1158543 (JP)
Inventors: RUIKE, Yoshinao; (SG).
TU, Wenjie; (SG).
KURAMOCHI, Taichi; (SG).
SHIMADA, Hideaki; (JP).
SUN, Yang; (SG).
KANAMORI, Masakazu; (SG)
Agent: HARUNA, Masao; (JP).
SHIMIZU, Hatsushi; (JP).
YAMAGUCHI, Hirotaka; (JP).
OSAKABE, Suguru; (JP).
INOUE, Ryuichi; (JP).
SATO, Toshimitsu; (JP).
SHIMMI, Hirokazu; (JP).
KOBAYASHI, Tomohiko; (JP).
KODERA, Hideki; (JP).
OHZEKI, Masato; (JP).
IGARASHI, Yoshihiro; (JP).
KAWAMOTO, Kazuya; (JP)
Priority Data:
2016-172728 05.09.2016 JP
Title (EN) ANTI-TGF-BETA 1 ANTIBODIES AND METHODS OF USE
(FR) ANTICORPS ANTI-TGF-BETA 1 ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present inventors have conducted diligent studies and consequently created anti-TGF-beta 1 antibodies which inhibit a protease mediated activation of TGF-beta 1. It has been reported that latent TGF-beta is cleaved to release active TGF-beta by proteases. However, surprisingly, the present inventors have found that the anti-TGF-beta 1 antibodies inhibit a protease mediated activation of latent TGF-beta 1 without inhibiting protease mediated cleavage of the LAP region of latent TGF-beta 1, and have in vivo anti-fibrotic effects as well.
(FR)Les présents inventeurs ont mis en oeuvre des études diligentes et par conséquent des anticorps anti-TGF-bêta 1 créés qui inhibent une activation induite par une protéase de TGF-bêta 1. Il a été rapporté que le TGF-bêta latent est clivé pour libérer le TGF-bêta actif par les protéases. Cependant, de manière surprenante, les présents inventeurs ont découvert que les anticorps anti-TGF-bêta 1 inhibent une activation induite par une protéase du TGF-bêta 1 latent sans inhiber le clivage induit par une protéase de la région LAP du TGF-bêta latent, et ont des effets anti-fibrotiques in vivo ainsi que des effets anti-fibrotiques in vivo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)