Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018043631) PROTEIN COMPRISING REPEATEDLY ARRANGED POLY(AMINO ACID) OR POLYPEPTIDE, AND CHEMICAL SYNTHESIS METHOD THEREFOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/043631 International Application No.: PCT/JP2017/031317
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
C07K 14/00 (2006.01) ,C07K 1/10 (2006.01) ,C08G 69/10 (2006.01) ,C12P 21/02 (2006.01) ,D01F 4/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
10
using coupling agents
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69
Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
02
Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids
08
derived from amino carboxylic acids
10
Alpha-amino-carboxylic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
F
CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
4
Monocomponent artificial filaments or the like of proteins; Manufacture thereof
02
from fibroin
Applicants:
国立研究開発法人理化学研究所 RIKEN [JP/JP]; 埼玉県和光市広沢2番1号 2-1, Hirosawa, Wako-shi, Saitama 3510198, JP
Inventors:
沼田 圭司 NUMATA Keiji; JP
土屋 康佑 TSUCHIYA Kousuke; JP
Agent:
牛木 護 USHIKI Mamoru; JP
Priority Data:
2016-16901231.08.2016JP
Title (EN) PROTEIN COMPRISING REPEATEDLY ARRANGED POLY(AMINO ACID) OR POLYPEPTIDE, AND CHEMICAL SYNTHESIS METHOD THEREFOR
(FR) PROTÉINE COMPRENANT UN POLY (ACIDE AMINÉ) OU UN POLYPEPTIDE AGENCÉ DE FAÇON RÉPÉTÉE ET SON PROCÉDÉ DE SYNTHÈSE CHIMIQUE
(JA) ポリアミノ酸又はポリペプチドが反復配列したタンパク質、及びその化学合成法
Abstract:
(EN) The present invention establishes a process for producing a protein using a chemical synthesis method, in particular, using both an enzymatic polymerization method and a block copolymerization method. Provided are: a protein produced by the process and having properties that are similar or superior to those of natural silk protein; and products produced from the protein, such as a resin, a fiber, and a film. The present invention provides: a protein comprising a poly(amino acid) formed from a single amino acid and/or a polypeptide formed from a plurality of amino acids, the protein being a block copolymer which comprises at least two kinds of blocks that each are the poly(amino acid) or the polypeptide, the at least two kinds differing in the kind of amino acid and/or in amino-acid makeup, the blocks having been repeatedly arranged by block copolymerization; and products produced from the protein.
(FR) La présente invention porte sur un procédé de production d'une protéine à l'aide d'un procédé de synthèse chimique, en particulier, à l'aide d'un procédé de polymérisation enzymatique et d'un procédé de copolymérisation en bloc. L'invention concerne : une protéine produite par le procédé et ayant des propriétés similaires ou supérieures à celles de la protéine de soie naturelle ; et des produits fabriqués à partir de la protéine, telle qu'une résine, une fibre et un film. La présente invention concerne : une protéine comprenant un poly (acide aminé) formé à partir d'un seul acide aminé et/ou d'un polypeptide formé à partir d'une pluralité d'acides aminés, la protéine étant un copolymère séquencé qui comprend au moins deux types de blocs qui sont chacun le poly (acide aminé) ou le polypeptide, les deux types, au moins, diffèrent dans le type d'acide aminé et/ou dans la forme d'acides aminés, les blocs ayant été agencés de façon répétée par copolymérisation séquencée ; et des produits produits à partir de la protéine.
(JA) 化学合成法、特に酵素重合法及びブロック共重合法を使用するタンパク質の製造方法を確立し、本方法によって製造される天然シルクタンパク質に類似又は向上した特性を有するタンパク質、さらに、該タンパク質より製造される樹脂、繊維及びフィルム等の製品を提供する。 本発明は、単一のアミノ酸からなるポリアミノ酸及び/又は複数種のアミノ酸からなるポリペプチドを含むタンパク質であって、アミノ酸の種類及び/又は組成比が相違する前記ポリアミノ酸及び前記ポリペプチドの少なくとも2種がブロック共重合により反復配列しているブロック共重合体であるタンパク質、及び、該タンパク質から製造される製品を提供する。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)