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1. (WO2018043567) COMPOUND FOR REMOVING HUMAN PLURIPOTENT STEM CELLS

Pub. No.:    WO/2018/043567    International Application No.:    PCT/JP2017/031165
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Aug 31 01:59:59 CEST 2017
IPC: C07D 311/80
C07D 491/22
C12N 5/0735
C12N 5/074
C12N 5/0789
C12N 5/0797
C12N 5/10
Applicants: KYOTO UNIVERSITY
国立大学法人京都大学
Inventors: UESUGI Motonari
上杉 志成
Di Mao
茅 迪
KAWASE Eihachiro
川瀬 栄八郎
Title: COMPOUND FOR REMOVING HUMAN PLURIPOTENT STEM CELLS
Abstract:
The purpose of the present invention is to discover a cytotoxic anticancer drug that serves as a common substrate for both ABCB1 and ABCG2 which are suppressed in human pluripotent stem cells, and to provide a method for efficiently removing undifferentiated cells using said drug. Specifically, the present invention pertains to: a compound represented by formula (I); synthesis intermediates thereof; a method in which said compound is used to remove undifferentiated cells in a cell population in which the differentiation of stem cells has been induced; and a drug that selectively damages cells that express ABCB1 and ABCG2 transporters, the drug containing said compound as an active ingredient.