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1. (WO2018042385) METHODS AND COMPOSITIONS INVOLVING INTERLEUKIN-6 RECEPTOR ALPHA-BINDING SINGLE CHAIN VARIABLE FRAGMENTS
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Pub. No.: WO/2018/042385 International Application No.: PCT/IB2017/055281
Publication Date: 08.03.2018 International Filing Date: 01.09.2017
IPC:
A61K 39/395 (2006.01) ,A61K 51/10 (2006.01) ,C07K 16/28 (2006.01) ,C07K 14/705 (2006.01)
[IPC code unknown for A61K 39/395][IPC code unknown for A61K 51/10][IPC code unknown for C07K 16/28][IPC code unknown for C07K 14/705]
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607, US
Inventors:
CHEN, Yvonne Yu-Hsuan; US
LIN, Meng-Yin; US
Agent:
STELLMAN, Laurie; US
SHISHIMA, Gina; US
Priority Data:
62/383,23702.09.2016US
62/440,99130.12.2016US
62/443,50906.01.2017US
Title (EN) METHODS AND COMPOSITIONS INVOLVING INTERLEUKIN-6 RECEPTOR ALPHA-BINDING SINGLE CHAIN VARIABLE FRAGMENTS
(FR) MÉTHODES ET COMPOSITIONS IMPLIQUANT DES FRAGMENTS VARIABLES À CHAÎNE UNIQUE (SCFV) DE LIAISON AU RÉCEPTEUR ALPHA DE L'INTERLEUKINE-6
Abstract:
(EN) Disclosed are compositions comprising an isolated chimeric interleukin 6 receptor alpha (IL-6Rα) binding protein or cells expressing an isolated chimeric IL-6Rα binding protein. The isolated IL-6Rα chimeric binding protein and cells expressing the protein may be used in methods of treating cancer and reducing the risk of cytokine release syndrome.
(FR) L'invention concerne des compositions comprenant une protéine de liaison au récepteur alpha de l'interleukine 6 (IL-6Rα) chimérique isolée ou des cellules exprimant une protéine de liaison IL-6Rα chimérique isolée. La protéine de liaison chimérique IL-6Rα isolée et les cellules exprimant ladite protéine peuvent être utilisées dans des méthodes de traitement du cancer et de réduction du risque de syndrome de libération de cytokine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)