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1. (WO2018042384) COMPOSITIONS OF MEDICINAL PLANTS FOR REDUCING THE EFFECTS OF AGING, PREVENTION AND TREATMENT OF AGE-RELATED NEURODEGENERATIVE DISEASES, AND TREATMENT OF ANXIETY AND SLEEP DISORDERS
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WHAT IS CLAIMED IS:

1. A composition comprising an extract or a dried powder of an extract, the extract being derived from a mixture of plants, the plants comprising:

(a) Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, and Caulis Polygonum multiflorum Thunb, the composition being free of Flos Albizia julibrissin Durazz

(b) Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, and Flos Albizia julibrissin Durazz, the composition being free of Caulis Polygonum multiflorum Thunb;

(c) Radix Bupleurum chinense DC, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz, the composition being free of Rhizoma Corydalis yanhusuo WT Wang;

(d) Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz, the composition being free of Radix Bupleurum chinense DC;

(e) Radix Bupleurum chinense DC and Rhizoma Corydalis yanhusuo WT Wang, the composition being free of Caulis Polygonum multiflorum Thunb and Flos Albizia julibrissin Durazz.

(f) Radix Bupleurum chinense DC and Caulis Polygonum multiflorum Thunb, the composition being free of Rhizoma Corydalis yanhusuo WT Wang and Flos Albizia julibrissin Durazz;

(g) Radix Bupleurum chinense DC and Flos Albizia julibrissin Durazz, the composition being free of Rhizoma Corydalis yanhusuo WT Wang, and Caulis Polygonum multiflorum Thunb;

(h) Rhizoma Corydalis yanhusuo WT Wang and Caulis Polygonum multiflorum Thunb, the composition being free of Radix Bupleurum chinense DC and Flos Albizia julibrissin Durazz; or

(i) Caulis Polygonum multiflorum Thunb and Flos Albizia julibrissin Durazz, the composition being free of Radix Bupleurum chinense DC and Rhizoma Corydalis yanhusuo WT Wang.

2. The composition of claim 1 wherein the plants comprise the plants of 1(a) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1.4: 1 : 1 of Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, and Caulis Polygonum multiflorum Thunb.

3. The composition of claim 1 wherein the plants comprise the plants of 1(b) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1.4: 1 : 1 of Radix Bupleurum chinense DC:Rhizoma Corydalis yanhusuo WT Wang:Flos Albizia julibrissin Durazz.

4. The composition of claim 1 wherein the plants comprise the plants of 1(c) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1.4: 1 : 1 of Radix Bupleurum chinense OC.CauWs Polygonum multiflorum Thunb:Flos Albizia julibrissin Durazz.

5. The composition of claim 1 wherein the plants comprise the plants of 1(d) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1 : 1 : 1 of Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz.

6. The composition of claim 1 wherein the plants comprise the plants of 1(e) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1.4: 1 of Radix Bupleurum chinense DC and Rhizoma Corydalis yanhusuo WT Wang.

7. The composition of claim 1 wherein the plants comprise the plants of 1(f) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about

1.4: 1 of Radix Bupleurum chinense DC and Caulis Polygonum multiflorum Thunb.

8. The composition of claim 1 wherein the plants comprise the plants of 1(g) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1.4: 1 of Radix Bupleurum chinense DC and Flos Albizia julibrissin Durazz.

9. The composition of claim 1 wherein the plants comprise the plants of 1(h) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1 : 1 of Rhizoma Corydalis yanhusuo WT Wang and Caulis Polygonum multiflorum Thunb.

10. The composition of claim 1 wherein the plants comprise the plants of l(i) derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1 : 1 of Caulis Polygonum multiflorum Thunb and Flos Albizia julibrissin Durazz.

11. The composition of any one of claims 1-10 which consists essentially of the extract or the dried powder of the extract.

12. A pharmaceutical formulation or herbal supplement comprising the composition of any one of claims 1-11 and an excipient.

13. The pharmaceutical formulation or herbal supplement of claim 12 wherein the active ingredient consists essentially of the composition.

14. A method of reducing the effect of aging or treating anxiety and/or inducing sleep, the method comprising administering to a subject in need thereof the composition of claim 1 or 3 comprising the plants of 1(b), or the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(b).

15. A method of reducing the effect of aging and/or treating anxiety, the method comprising administering to a subject in need thereof the composition of claim 1 or 4 comprising the plants of 1(c), or the pharmaceutical formulation or herbal supplement of claim

12 or 13 comprising the plants of 1(c).

16. A method of reducing the effect of aging, the method comprising administering to a subject in need thereof either the composition of any one of claims 1, 2, 6, 7, or 9 comprising the plants of 1(a), 1(e), 1(f) or 1(h); a composition comprising an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Cauhs Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz; , the pharmaceutical formulation or herbal supplement of claim 12 or

13 comprising the plants of 1(a), 1(e), 1(f) or 1(h); or the pharmaceutical formulation or herbal supplement comprising a composition comprised of an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis

yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz and an excipient.

17. A method of treating anxiety and/or inducing sleep, the method comprising administering to a subject in need thereof the composition of any one of claims 1, 5 or 10 comprising the plants of 1(d) or l(i), or the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(d) or l(i).

18. A method of treating anxiety, the method comprising administering to a subject in need thereof the herbal composition of claim 1 or 8 comprising the plants of 1(g), or the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of

1(g).

19. A method for the prevention and/or treatment of Alzheimer's disease, the method comprising administering to a subject in need thereof either the composition of any one of claims 1, 2, 3, 4, 6, 7, or 9 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f) or 1(h); a composition comprising an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz ; the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f) or 1(h); or a pharmaceutical formulation or herbal supplement comprising a composition comprised of an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz and an excipient.

20. A method for the prevention and/or treatment of Parkinson's disease, the method comprising administering to a subject in need thereof either the composition of any one of claims 1, 2, 3, 4, 6, 7, or 9 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f), or 1(h); a composition comprising an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz ; the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f) or 1(h); or a pharmaceutical formulation or herbal supplement comprising a composition comprised of an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz and an excipient.

21. The method of any one of claims 16, 19 or 20, wherein the plants comprise the plants of Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1.4: 1 : 1 : 1 of Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz.

22. A method of making a pharmaceutical formulation or herbal supplement of the composition in any one of claims 1-11, comprising:

(i) heating a first powder of one or more of the plants in the presence of a solvent to form a suspension;

(ii) collecting the supernatant from the suspension;

(iii) heating the residue from the suspension in the presence of a second solvent to form a second suspension;

(iv) collecting the supernatant from the second suspension;

(v) combining the supernatants to form a third suspension;

(vi) filtering the third suspension to form a filtered third suspension;

(vii) heating the filtered third suspension to form a concentrate;

(viii) dehydrating the concentrate to form a dehydrated residue;

(ix) forming a second powder from the dehydrated residue;

(x) drying the second powder to form a powdered extract of the one or more of the plants;

(xi) if the powdered extract of step (x) comprises an extract of the plants from which the composition is derived, combining the powdered extract with an excipient to yield the pharmaceutical formulation or herbal supplement comprising the composition; and

(xii) optionally repeating steps (i)-(iv) and optionally repeating any one or more of steps (v)-(x) for any remaining plants from which the composition is derived, combining each of the second suspensions, the third suspensions, the filtered third suspensions, the concentrates, the dehydrated residues, or the second powders to form a final powdered extract, and mixing the final powdered extract with an excipient to yield the pharmaceutical formulation or herbal supplement comprising the composition.

23. The method of claim 22 wherein the first powder of step (i) is a powder blend of the plants in the composition, and the powdered extract of step (x) comprises an extract of the plants from which the composition is derived.

24. The method of claim 22 wherein the first powder of step (i) is a powder of one of the plants in the composition, steps (i)-(iv) are repeated for each of the plants from which the composition is derived, one or more of steps (v)-(x) are repeated for each of the plants from which the composition is derived, and each of the second suspensions, the third suspensions, the filtered third suspensions, the concentrates, the dehydrated residues, or the second powders for each of the plants are combined to form a final powdered extract which is mixed with the excipient to yield the pharmaceutical formulation or herbal supplement.

25. The method of any one of claims 22-24 wherein the solvent and/or the second solvent comprises acetic acid.

26. A pharmaceutical formulation or herbal supplement for use in reducing the effect of aging or treating anxiety and/or inducing sleep, wherein the therapy comprises administering the the composition of claim 1 or 3 comprising the plants of 1(b), or the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(b) to a subject in need thereof.

27. A pharmaceutical formulation or herbal supplement for use in reducing the effect of aging and/or treating anxiety, wherein the therapy comprises administering to a subject in need thereof the composition of claim 1 or 4 comprising the plants of 1(c), or the

pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(c).

28. A pharmaceutical formulation or herbal supplement for use in reducing the effect of aging, wherein the therapy comprises administering to a subject in need thereof the composition of any one of claims 1, 2, 6, 7, or 9 comprising the plants of 1(a), 1(e), 1(f) or 1(h); a composition comprising an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz; , the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(a), 1(e), 1(f) or 1(h); or the pharmaceutical formulation or herbal supplement comprising a composition comprised of an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz and an excipient.

29. A pharmaceutical formulation or herbal supplement for use in treating anxiety and/or inducing sleep, wherein the therapy comprises administering to a subject in need thereof the composition of any one of claims 1, 5 or 10 comprising the plants of 1(d) or l(i), or the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(d) or l(i).

30. A pharmaceutical formulation or herbal supplement for use in treating anxiety, wherein the therapy comprises administering to a subject in need thereof the herbal composition of claim 1 or 8 comprising the plants of 1(g), or the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(g).

31. A pharmaceutical formulation or herbal supplement for use in the prevention and/or treatment of Alzheimer's disease, wherein the therapy comprises administering to a subject in need thereof either the composition of any one of claims 1, 2, 3, 4, 6, 7, or 9 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f) or 1(h); a composition comprising an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz ; the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f) or 1(h); or a pharmaceutical formulation or herbal supplement comprising a composition comprised of an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz and an excipient.

32. A pharmaceutical formulation or herbal supplement for use in the prevention and/or treatment of Parkinson's disease, wherein the therapy comprises administering to a subject in need thereof either the composition of any one of claims 1, 2, 3, 4, 6, 7, or 9 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f), or 1(h); a composition comprising an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz ; the pharmaceutical formulation or herbal supplement of claim 12 or 13 comprising the plants of 1(a), 1(b), 1(c), 1(e), 1(f) or 1(h); or a pharmaceutical formulation or herbal supplement comprising a composition comprised of an extract or a dried powder of an extract, the extract being derived from a mixture of plants or comprising a mixture of extracts derived from the plants, the plants comprising Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz and an excipient.

33. The pharmaceutical formulation or herbal supplement of any one of claims 28, 31 or 32, wherein the plants comprise the plants of Radix Bupleurum chinense DC, Rhizoma

Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz derived from a powder blend of each plant having a weight ratio of the powder of each plant of about 1.4: 1 : 1 : 1 of Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz.