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1. (WO2018042384) COMPOSITIONS OF MEDICINAL PLANTS FOR REDUCING THE EFFECTS OF AGING, PREVENTION AND TREATMENT OF AGE-RELATED NEURODEGENERATIVE DISEASES, AND TREATMENT OF ANXIETY AND SLEEP DISORDERS
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Pub. No.: WO/2018/042384 International Application No.: PCT/IB2017/055279
Publication Date: 08.03.2018 International Filing Date: 01.09.2017
IPC:
A61K 36/50 (2006.01) ,A61K 36/233 (2006.01) ,A61P 25/22 (2006.01) ,A61P 25/20 (2006.01) ,A61P 25/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
50
Fumariaceae (Fumitory family), e.g. bleeding heart
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
23
Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
233
Bupleurum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
20
Hypnotics; Sedatives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
Applicants:
PHARMACOGENETICS LIMITED [CN/CN]; Unit C9, 5/F, Wah Lok Industrial Centre, Phase II, 31-35 Shan Mei Street Shatin, N.T. Hong Kong, CN
Inventors:
XUE, Hong; CN
Priority Data:
15/255,87602.09.2016US
Title (EN) COMPOSITIONS OF MEDICINAL PLANTS FOR REDUCING THE EFFECTS OF AGING, PREVENTION AND TREATMENT OF AGE-RELATED NEURODEGENERATIVE DISEASES, AND TREATMENT OF ANXIETY AND SLEEP DISORDERS
(FR) COMPOSITIONS DE PLANTES MÉDICINALES POUR COMBATTRE LES EFFETS DU VIEILLISSEMENT, PRÉVENTION ET TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES LIÉES À L'ÂGE, ET TRAITEMENT DE L'ANXIÉTÉ ET DES TROUBLES DU SOMMEIL
Abstract:
(EN) Compositions comprising extracts prepared from mixtures of the herbal plants Radix Bupleurum chinense DC ("B"), Rhizoma Corydalis yanhusuo WT Wang ("Y"), Caulis Polygonum multiflorum Thunb ("P") and Flos Albizia julibrissin Durazz ("A") are provided. The BYP, BYA, BPA, BY, BP, YP and BYPA extracts significantly decreased one or more of the effects of accelerated aging in mice exposed to D-galactose, including spatial memory deficit, and elevated oxidative stress marker malondialdehyde and pro-inflammatory cytokines TNF-alpha and IL-6 in the brain, indicating efficacy in reducing the damage of aging, and preventing and treating Alzheimer's disease and/or Parkinson's disease. Anxiolysis by the BYA, BPA, YPA, BA and PA extracts indicates efficacy for treating anxiety disorders, and the sedative effect of the BYA, YPA and PA extracts indicates efficacy for treating sleep disorders. None of the extracts significantly induced alteration in locomotor activity, decreased muscle coordination, or anterograde amnesia at the maximum oral dose tested.
(FR) L'invention concerne des compositions comprenant des extraits préparés à partir de mélanges des plantes médicinales suivantes : racine de Bupleurum chinense DC ("B"), rhizome de Corydalis yanhusuo WT Wang ("Y"), tige de Polygonum multiflorum Thunb ("P") et fleur d'Albizia julibrissin Durazz ("A"). Les extraits BYP, BYA, BPA, BY, BP, YP et BYPA diminuent significativement un ou plusieurs des effets du vieillissement accéléré chez la souris exposée au D-galactose, y compris le déficit de la mémoire spatiale, et augmentent significativement dans le cerveau un marqueur du stress oxydatif, le malondialdéhyde, et les cytokines pro-inflammatoires TNF-alpha et IL-6, indiquant qu'ils sont efficaces pour combattre les lésions liées au vieillissement, et pour prévenir et traiter la maladie d'Alzheimer et/ou la maladie de Parkinson. L'anxiolyse obtenue grâce aux extraits BYA, BPA, YPA, BA et PA indique une efficacité dans le traitement des troubles de l'anxiété, et l'effet sédatif des extraits BYA, YPA et PA indique une efficacité pour le traitement des troubles du sommeil. Aucun des extraits, lorsque pris à la dose orale maximale testée, n'a significativement induit d'altération de l'activité locomotrice ou une moins bonne coordination musculaire, ni d'amnésie antérograde.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)