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1. (WO2018042182) COMPOSITIONS AND USES THEREOF

Pub. No.:    WO/2018/042182    International Application No.:    PCT/GB2017/052541
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Sat Sep 02 01:59:59 CEST 2017
IPC: A61K 39/395
A61P 25/28
Applicants: MANCHESTER METROPOLITAN UNIVERSITY
Inventors: SLEVIN, Mark
BOLTZE, Johannes
POTEMPA, Lawrence A.
Title: COMPOSITIONS AND USES THEREOF
Abstract:
The present invention relates to compositions for use in the treatment, prevention or management of neurological degeneration or dementia, comprising inhibitors or antagonists of monomeric C-reactive protein (mCRP), and optionally, the inhibitor or antagonist modulates the activity ofthe cholesterol binding region (CBR) and/or the C-terminal octapeptide region of mCRP.