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1. (WO2018042178) MODIFIED FACTOR H BINDING PROTEIN
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Pub. No.: WO/2018/042178 International Application No.: PCT/GB2017/052535
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
A61K 39/095 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
095
Neisseria
Applicants:
OXFORD UNIVERSITY INNOVATION LIMITED [GB/GB]; Buxton Court 3 West Way Oxford OX2 0SZ, GB
Inventors:
TANG, Christoph M; GB
Agent:
BARKER BRETTELL LLP; 100 Hagley Road Edgbaston Birmingham West Midlands B16 8QQ, GB
Priority Data:
1614687.031.08.2016GB
Title (EN) MODIFIED FACTOR H BINDING PROTEIN
(FR) PROTÉINE DE LIAISON AU FACTEUR H MODIFIÉE
Abstract:
(EN) The invention relates to a modified factor H binding protein (fHbp), comprising fHbp, or a variant thereof, modified with the addition of at least one exogenous peptide loop; and associated nucleic acid, compositions, and uses. The invention further relates to treatment or prevention of a pathogenic infection or colonisation of a subject using the modified factor H binding protein (fHbp).
(FR) L'invention concerne une protéine de liaison au facteur H (fHbp) modifiée, comprenant fHbp ou un variant de celui-ci, modifiée par l'ajout d'au moins une boucle de peptide exogène ; et un acide nucléique, des compositions et des utilisations associés. L'invention concerne également le traitement ou la prévention d'une infection ou d'une colonisation pathogène chez un individu, au moyen de la protéine de liaison au facteur H (fHbp) modifiée.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)