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1. (WO2018042152) METHOD AND APPARATUS FOR QUANTIFYING LUNG FUNCTION

Pub. No.:    WO/2018/042152    International Application No.:    PCT/GB2017/052397
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Wed Aug 16 01:59:59 CEST 2017
IPC: A61B 5/08
A61B 5/091
G06F 19/00
A61B 5/097
A61B 5/00
Applicants: OXFORD UNIVERSITY INNOVATION LIMITED
Inventors: ROBBINS, Peter Alistair
HANCOCK, Gus
RITCHIE, Grant
MOUNTAIN, James
O'NEILL, David
WHITELEY, Jonathan
CIAFFONI, Luca
COUPER, John
Title: METHOD AND APPARATUS FOR QUANTIFYING LUNG FUNCTION
Abstract:
A method and apparatus for non-invasive assessment of lung inhomogeneity by accurate high temporal resolution measurement of respiratory gas flows at the mouth during steady state breathing and inert gas wash-in or wash-out and using these measurements to fit a mathematical model of the inhomogeneous lung. The model of the lung is based on modelling the lung as plural alveolar compartments each having an identical volume at functional residual capacity, but varying in its fractional share of total lung compliance, total pulmonary vascular conductance and total anatomical deadspace. A bivariate log- normal distribution of the lung compliance and pulmonary vascular conductance is used, together with a normal distribution of deadspace fraction. The model is fitted to the measurements using non-linear regression and the distribution of ventilation: perfusion ratios, lung compliance: volume ratios, lung vascular conductance: volume ratios and lung deadspace: volume ratios obtained from the fitted model are indicative of the airway condition and thus lung function of the subject.