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1. (WO2018042141) USE OF TRYPTOPHAN METABOLITES FOR TREATING MUSCLE ATROPHY
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Pub. No.: WO/2018/042141 International Application No.: PCT/FR2017/052338
Publication Date: 08.03.2018 International Filing Date: 05.09.2017
IPC:
A61K 31/47 (2006.01) ,A61P 21/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
Applicants:
METABRAIN RESEARCH [FR/FR]; 4 avenue du Président François Mitterand 91380 CHILLY MAZARIN, FR
Inventors:
RAYNAL, Sophie, N.; FR
AUDET, Annick; FR
AUTIER, Valérie; FR
CHARON, Christine; FR
DURAND, Jean-Denis; FR
KERGOAT, Micheline; FR
Agent:
MENDELSOHN, Isabelle; FR
HUBERT, Philippe; FR
HART-DAVIS, Jason; FR
NEVANT, Marc; FR
MARRO, Nicolas; FR
LE ROUX, Martine; FR
CHANTRAINE, Sylvie; FR
MENA, Sandra; FR
Priority Data:
165823905.09.2016FR
Title (EN) USE OF TRYPTOPHAN METABOLITES FOR TREATING MUSCLE ATROPHY
(FR) UTILISATION DE METABOLITES DU TRYPTOPHANE DANS LE TRAITEMENT DE L'ATROPHIE MUSCULAIRE
Abstract:
(EN) The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.
(FR) La présente invention concerne un métabolite du tryptophane choisi parmi l'acide kynurénique, l'acide anthranilique, l'acide quinolinique, l'acide picolinique, l'acide quinaldique et leurs mélanges ou un énantiomère, diastéréoisomère, hydrate, solvate, tautomère, mélange racémique ou sel pharmaceutiquement acceptable de celui-ci pour utilisation à titre de médicament destiné à l'augmentation et/ou au maintien de la masse et/ou de la puissance musculaire chez un mammifère, et en particulier destiné au traitement et/ou à la prévention de l'atrophie musculaire chez les mammifères et/ou pour favoriser l'accroissement musculaire des mammifères faisant de l'exercice et visant à augmenter la masse et/ou la qualité et/ou la puissance musculaire, en prévention de l'apparition de symptômes sarcopéniques ou en rééducation suite à une perte musculaire et/ou pour améliorer le temps de récupération après un effort physique intense.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)