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1. (WO2018042018) IRRADIATION TREATMENT OF NEUROLOGICAL SENSATIONS BY PHOTOABLATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/042018 International Application No.: PCT/EP2017/072014
Publication Date: 08.03.2018 International Filing Date: 01.09.2017
IPC:
A61K 38/18 (2006.01) ,A61K 51/08 (2006.01) ,A61P 25/02 (2006.01) ,A61K 38/20 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
02
for peripheral neuropathies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
20
Interleukins
Applicants: EUROPEAN MOLECULAR BIOLOGY LABORATORY[DE/DE]; Meyerhofstrasse 1 69117 Heidelberg, DE
Inventors: HEPPENSTALL, Paul; IT
DHANDAPANI, Rahul; IN
PORTULANO, Carla; IT
Agent: BOEHMERT & BOEHMERT; David KUTTENKEULER Pettenkoferstrasse 22 80336 Munich, DE
Priority Data:
16187087.802.09.2016EP
17178123.027.06.2017EP
Title (EN) IRRADIATION TREATMENT OF NEUROLOGICAL SENSATIONS BY PHOTOABLATION
(FR) TRAITEMENT D'IRRADIATION DE SENSATIONS NEUROLOGIQUES PAR PHOTOABLATION
Abstract:
(EN) The present invention relates to an approach for the treatment of adverse neurological sensations in a certain body surface area such as the skin, in particular treatment of pain or itching. The invention is based on the finding that administration of a targeting molecule which specifically binds a cell or receptor responsible for the adverse sensation in the respective body surface area of a patient, and which is coupled/conjugated to a photosensitive inhibitor or cytotoxic agent can enable the irradiation dependent ablation of cells responsible for the sensation. This approach allows a targeted and specific treatment of body surface areas by irradiation. Provided are conjugate compounds for use in the photoablation treatment of the invention and pharmaceutical compositions which comprise these compounds.
(FR) La présente invention concerne une approche pour le traitement de sensations neurologiques indésirables dans une certaine zone de surface corporelle telle que la peau, en particulier le traitement d'une douleur ou de démangeaisons. L'invention repose sur la découverte selon laquelle l'administration d'une molécule de ciblage qui se lie spécifiquement à une cellule ou un récepteur responsable de la sensation indésirable dans la zone de surface corporelle concernée d'un patient, et qui est couplée/conjuguée à un inhibiteur photosensible ou à un agent cytotoxique, peut permettre l'ablation dépendante de l'irradiation de cellules responsables de la sensation. Cette approche permet un traitement ciblé et spécifique de zones de surface corporelle par irradiation. L'invention concerne des composés conjugués destinés à être utilisés dans le traitement de photoablation de l'invention et des compositions pharmaceutiques qui comprennent ces composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)