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1. (WO2018041981) IMMUNOMODULATION AFTER LOCOREGIONAL ANTI-TUMORAL TREAMENT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/041981 International Application No.: PCT/EP2017/071924
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
A61K 9/06 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/36 (2006.01) ,A61K 38/19 (2006.01) ,A61K 39/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
04
Mycobacterium, e.g. Mycobacterium tuberculosis
Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)[FR/FR]; 101, rue de Tolbiac 75013 PARIS, FR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)[FR/FR]; 3, rue Michel Ange 75016 PARIS, FR
UNIVERSITE PARIS DESCARTES[FR/FR]; 12, rue de l'Ecole de Médecine 75006 PARIS, FR
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS[FR/FR]; 3, avenue Victoria 75004 PARIS, FR
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS[FR/FR]; 11 rue Pierre et Marie Curie 75005 PARIS, FR
UNIVERSITE DE VERSAILLES-ST QUENTIN EN YVELINES[FR/FR]; 55 avenue de Paris 78035 VERSAILLES CEDEX, FR
Inventors: MALAFOSSE, Robert; FR
MIGNET, Nathalie; FR
BOUDY, Vincent; FR
SEGUIN, Johanne; FR
LEMDANI, Kathia; FR
CAPRON, Claude; FR
Agent: REGIMBEAU; 20, rue de Chazelles 75847 PARIS CEDEX 17, FR
Priority Data:
16306102.131.08.2016EP
17305558.316.05.2017EP
Title (EN) IMMUNOMODULATION AFTER LOCOREGIONAL ANTI-TUMORAL TREAMENT
(FR) IMMUNOMODULATION APRÈS UN TRAITEMENT ANTITUMORAL LOCO-RÉGIONALE
Abstract:
(EN) The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.
(FR) La présente invention porte sur un polymère d'hydrogel thermosensible comprenant au moins un copolymère thermosensible, une solution aqueuse et un excipient mucoadhésif. Ledit hydrogel polymère thermosensible comprend, en outre, au moins un adjuvant immunostimulateur, et/ou au moins une cytokine, et/ou au moins une chimiokine et/ou au moins une protéine de choc thermique. Un autre élément de l'invention est un polymère d'hydrogel thermosensible, élaboré d'après l'invention, destiné à être utilisé dans le traitement de tumeurs, ou de métastases, chez un sujet atteint d'un cancer, de préférence un cancer métastatique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)