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1. (WO2018041960) IN VITRO METHOD FOR PREDICTING THE RISK OF DEVELOPING A BREAST LATE EFFECT AFTER RADIOTHERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/041960 International Application No.: PCT/EP2017/071887
Publication Date: 08.03.2018 International Filing Date: 31.08.2017
IPC:
G01N 33/574 (2006.01) ,G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants: INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER[FR/FR]; Val d'Aurelle (ICM) 208 Rue des Apothicaires 34090 MONTPELLIER, FR
Inventors: AZRIA, David; FR
GOURGOU, Sophie; FR
Agent: REGIMBEAU; 20, rue de Chazelles 75847 PARIS CEDEX 17, FR
Priority Data:
16306097.331.08.2016EP
Title (EN) IN VITRO METHOD FOR PREDICTING THE RISK OF DEVELOPING A BREAST LATE EFFECT AFTER RADIOTHERAPY
(FR) PROCÉDÉ IN VITRO POUR PRÉDIRE LE RISQUE DE DÉVELOPPER UNE SÉQUELLE MAMMAIRE APRÈS UNE RADIOTHÉRAPIE
Abstract:
(EN) The present invention is drawn to a new diagnosis method and a calculator for predicting the risk of developing a breast late effect (BLE), which is defined as atrophic skin, telangiectasia, induration (fibrosis), necrosis or ulceration, in a subject after radiotherapy (RT), by using Radiation Induced late effect using T-Lymphocyte Apoptosis (RILA) and clinical parameters. The invention is also drawn to diagnosis kits for the implementation of the method and a nomogram.
(FR) La présente invention concerne un nouveau procédé de diagnostic et un calculateur visant à prédire le risque de développer une séquelle mammaire, qui est définie comme pouvant correspondre à une peau atrophique, une télangiectasie, une induration (fibrose), une nécrose ou une ulcération, chez un sujet après une radiothérapie (RT), à l'aide du procédé RILA (séquelle radio-induite utilisant l'apoptose des lymphocytes T) et des paramètres cliniques. L'invention concerne également des kits de diagnostic pour la mise en œuvre du procédé et un nomogramme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)