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1. (WO2018041947) IMIDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE OR INFLAMMATORY DISEASES OR CANCERS

Pub. No.:    WO/2018/041947    International Application No.:    PCT/EP2017/071868
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Fri Sep 01 01:59:59 CEST 2017
IPC: C07D 401/14
C07D 405/14
A61K 31/443
A61K 31/4433
A61K 31/4439
A61K 31/444
C07D 401/04
A61P 29/00
A61P 35/00
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
Inventors: BAXTER, Andrew
BROWN, John, Alexander
HIRST, David
HUMPHREYS, Philip
JONES, Katherine, Louise
PATEL, Vipulkumar, Kantibhai
Title: IMIDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE OR INFLAMMATORY DISEASES OR CANCERS
Abstract:
Compounds of formula (I) and salts thereof: Formula (I) wherein R1, R2, R3 and a are as defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain containing proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.