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1. (WO2018041921) MIXING DEVICE FOR THE PRODUCTION OF A LIQUID NUCLEIC ACID COMPOSITION
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Pub. No.: WO/2018/041921 International Application No.: PCT/EP2017/071815
Publication Date: 08.03.2018 International Filing Date: 30.08.2017
IPC:
C12Q 1/68 ,B01F 5/06 (2006.01) ,B01L 3/00 (2006.01) ,A61K 47/64 (2017.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
F
MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5
Flow mixers; Mixers for falling materials, e.g. solid particles
06
Mixers in which the components are pressed together through slits, orifices, or screens
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
[IPC code unknown for A61K 47/64]
Applicants:
CUREVAC AG [DE/DE]; Paul-Ehrlich-Str. 15 72076 Tübingen, DE
Inventors:
SONNTAG, Michael; DE
HELD, Bernd; DE
SALZ-SIEGWALT, Arne; DE
REICHERT, Isabel; DE
MÜLLER, Axel; DE
Agent:
MAIWALD PATENTANWALTS- UND RECHTSANWALTSGESELLSCHAFT MBH; Dr. Andrea Lasar Elisenhof, Elisenstrasse 3 80335 Munich, DE
Priority Data:
PCT/EP2016/07053331.08.2016EP
Title (EN) MIXING DEVICE FOR THE PRODUCTION OF A LIQUID NUCLEIC ACID COMPOSITION
(FR) DISPOSITIF DE MÉLANGE POUR LA PRODUCTION D'UNE COMPOSITION D'ACIDE NUCLÉIQUE LIQUIDE
Abstract:
(EN) The present invention relates to a mixing device for the production of a liquid nucleic acid composition, a hose routing comprising such mixing device, a mixing array comprising a plurality of such mixing devices and a method 5 for the production of a liquid nucleic acid composition. Further, several uses described herein are part of the present invention. The liquid nucleic acid composition may comprise at least a nanoparticle comprising a nucleic acid and a complexation partner. The mixing device comprises a first inlet tube for a first component comprising a liquid nucleic acid solution, a second inlet tube for a second component, a connecting element, and an outlet tube. The connecting element is configured to connect the first inlet tube and the second inlet tube to the outlet 0 tube. The outlet tube comprises a swirling element configured to introduce a swirling of the first component and/or the second component in the outlet tube to allow a mixing of the first component and the second component to produce the liquid nucleic acid composition.
(FR) La présente invention concerne un dispositif de mélange pour la production d'une composition d'acide nucléique liquide, un acheminement de tuyau comprenant un tel dispositif de mélange, un réseau de mélange comprenant une pluralité de tels dispositifs de mélange et un procédé 5 pour la production d'une composition d'acide nucléique liquide. En outre, plusieurs utilisations, telles que définies dans la description, font partie de la présente invention. La composition d'acide nucléique liquide peut comprendre au moins une nanoparticule comprenant un acide nucléique et un partenaire de complexation. Le dispositif de mélange comprend un premier tube d'entrée pour un premier composant comprenant une solution d'acide nucléique liquide, un second tube d'entrée pour un second composant, un élément de liaison et un tube de sortie. L'élément de liaison est configuré pour relier le premier tube d'entrée et le second tube d'entrée au tube de sortie 0. Le tube de sortie comprend un élément tourbillonnant conçu pour introduire un tourbillonnement du premier composant et/ou du second composant dans le tube de sortie pour permettre un mélange du premier composant et du second composant pour produire la composition d'acide nucléique liquide.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)