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1. (WO2018041853) METHOD FOR THE PREPARATION OF 3-(TRIFLUOROMETHYL)PYRAZINE-2-CARBOXYLIC ACID ESTERS

Pub. No.:    WO/2018/041853    International Application No.:    PCT/EP2017/071690
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Aug 31 01:59:59 CEST 2017
IPC: C07D 241/24
Applicants: LONZA LTD
Inventors: ZARAGOZA DOERWALD, Florencio
TAESCHLER, Christoph
CARREIRA, Erick
Title: METHOD FOR THE PREPARATION OF 3-(TRIFLUOROMETHYL)PYRAZINE-2-CARBOXYLIC ACID ESTERS
Abstract:
The invention discloses a method for the preparation of 3-(trifluoromethyl)pyrazine-2-carboxylic acid esters starting from alkyl 4,4,4-trifluoro-2-(hydroxyimino)-3-oxobutanoates by reaction with ethylenediamine.