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1. (WO2018041377) CAPPED CYCLODEXTRIN-HYDROPHOBIC MOIETY CONJUGATE, CYCLODEXTRIN SUPRAMOLECULAR POLYMER, AND CYCLODEXTRIN-siRNA COMPLEX AND METHOD OF SYNTHESIS THEREOF

Pub. No.:    WO/2018/041377    International Application No.:    PCT/EP2016/070892
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Tue Sep 06 01:59:59 CEST 2016
IPC: C08B 37/16
Applicants: SORBONNE UNIVERSITE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
UNIVERSITE PARIS DESCARTES
Inventors: SOLLOGOUB, Matthieu
CALVEZ, Vincent
MARCELIN, Anne-Geneviève
BOUTEILLER, Laurent
MENAND, Mickaël
EVENOU, Pierre
GOTHLAND, Adélie
COLESNIC, Dmitri
ROSSIGNOL, Julien
Title: CAPPED CYCLODEXTRIN-HYDROPHOBIC MOIETY CONJUGATE, CYCLODEXTRIN SUPRAMOLECULAR POLYMER, AND CYCLODEXTRIN-siRNA COMPLEX AND METHOD OF SYNTHESIS THEREOF
Abstract:
The invention relates to a capped cyclodextrin-hydrophobic moiety conjugate, to a supramolecular polymer formed of capped cyclodextrin-hydrophobic moiety conjugates according to the invention and to a siRNA-cyclodextrin complex comprising a supramolecular polymer according to the invention. The invention also relates to a method for manufacturing the capped cyclodextrin-hydrophobic moiety conjugate, the supramolecular polymer, the siRNA-cyclodextrin complex according to the invention. The capped cyclodextrin-hydrophobic moiety conjugate of the invention comprises a capped cyclodextrin group and at least one hydrophobic moiety bound by a first linker to one of the carbon atoms of the cap. The invention can be used for various applications in particular in the pharmaceutical field.