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1. (WO2018041268) NANOBODY VAGINAL ADMINISTRATION SYSTEM AND PREPARATION METHOD AND USE THEREOF
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Pub. No.: WO/2018/041268 International Application No.: PCT/CN2017/101026
Publication Date: 08.03.2018 International Filing Date: 08.09.2017
IPC:
A61K 9/00 (2006.01) ,A61K 39/395 (2006.01) ,A61K 39/44 (2006.01) ,A61K 47/36 (2006.01) ,A61K 47/32 (2006.01) ,A61K 47/42 (2017.01) ,A61K 47/38 (2006.01) ,C07K 16/00 (2006.01) ,A61P 15/02 (2006.01) ,A61P 31/00 (2006.01) ,A61P 15/00 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44
Antibodies bound to carriers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
02
for disorders of the vagina
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
山西纳安生物科技有限公司 NANOLATTIX BIOTECHNOLOGY CO. LTD. [CN/CN]; 中国山西省太原市 高新区南中环街529号清控创新基地 High Tech Zone, South Central Street, No. 529, Qing Kong Innovation Base Taiyuan, Shanxi 030006, CN
Inventors:
渠志灿 QU, Zhican; CN
李少平 LI, Shaoping; CN
Agent:
太原华弈知识产权代理事务所 TAIYUAN HUAYI INTELLECTUAL PROPERTY AGENCE; 中国山西省太原市 平阳路1号金茂数码国际中心A座19-D 19-D, Block A, Jinmao Centre No.1 Pingyang Road Taiyuan, Shanxi 030012, CN
Priority Data:
201610800512.503.09.2016CN
Title (EN) NANOBODY VAGINAL ADMINISTRATION SYSTEM AND PREPARATION METHOD AND USE THEREOF
(FR) SYSTÈME D'ADMINISTRATION VAGINALE DE NANOCORPS ET SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 纳米抗体阴道给药系统及制备方法和应用
Abstract:
(EN) Disclosed is a nanobody vaginal administration system, comprising a specific nanobody with biological activity and an antibody drug carrier that increases the stability and tissue penetrability of the nanobody, and the drug carrier includes, but is not limited to, one or more of water-soluble high molecular bio-carbohydrate gum matrix, polyvinyl alcohol, polyamino acid, glycerol, phospholipid, gelatin, sodium carboxymethylcellulose, collagen, and hydrolase inhibitor. The nano vaginal administration system can not only play a therapeutic role in the vaginal environment and the localised parts of organs nearby, but also penetrate the vaginal tissues and enter the blood circulation of the human body to play a role in a pre-set lesion site.
(FR) L'invention concerne un système d'administration vaginale de nanocorps, comprenant un nanocorps spécifique ayant une activité biologique et un support de médicament d'anticorps qui augmente la stabilité et la pénétrabilité du tissu du nanocorps, et le support de médicament comprend, mais n'est pas limitée à, une ou plusieurs matrices de gomme bio-glucidique hydrosoluble de masse moléculaire élevée, un alcool polyvinylique, un acide polyaminé, un glycérol, un phospholipide, une gélatine, une carboxyméthylcellulose sodique, un collagène et un inhibiteur d'hydrolase. Le système d'administration vaginale ne présente pas seulement un rôle thérapeutique dans l'environnement vaginal et les parties localisées d'organes proches, mais aussi peut pénétrer dans les tissus vaginaux et entrer dans la circulation sanguine du corps humain pour jouer un rôle dans un site de lésion prédéfini.
(ZH) 纳米抗体阴道给药系统,包括具有生物活性的特异性纳米抗体和增加纳米抗体稳定性和组织穿透性的抗体药物载体,所述药物载体包括但不限于水溶性高分子生物糖胶基质、聚乙烯醇、多聚氨基酸、甘油、磷脂、明胶、羧甲基纤维素钠、胶原蛋白、水解酶抑制剂中的一种或多种。所述的纳米阴道给药系统不仅可在阴道内环境和邻近器官的局部发挥治疗作用,还可穿透阴道组织进入人体血液循环,到预设病灶部位发挥作用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)