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1. (WO2018041112) SALT DERIVATIVE OF TETRAHYDROISOQUINOLINE AND CRYSTALLINE THEREOF AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/041112    International Application No.:    PCT/CN2017/099549
Publication Date: 08.03.2018 International Filing Date: 30.08.2017
IPC:
C07D 217/18 (2006.01), A61K 31/472 (2006.01), A61P 9/06 (2006.01)
Applicants: CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRY [CN/CN]; 4th Floor, Building 1, No. 1111 Halley Road,pudong New Area Shanghai 201203 (CN).
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY [CN/CN]; No. 1320 West Beijing Road Shanghai 200040 (CN)
Inventors: XIE, Meihua; (CN).
ZHANG, Fuli; (CN).
WU, Taizhi; (CN).
ZHONG, Jialiang; (CN)
Agent: SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC; 435 Guiping Road Shanghai 200233 (CN)
Priority Data:
201610786945.X 31.08.2016 CN
201610786957.2 31.08.2016 CN
Title (EN) SALT DERIVATIVE OF TETRAHYDROISOQUINOLINE AND CRYSTALLINE THEREOF AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) DÉRIVÉ DE SEL DE TÉTRAHYDROISOQUINOLÉINE ET SON CRISTALLIN, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 一种四氢异喹啉的盐衍生物及其晶体的制备方法和应用
Abstract: front page image
(EN)The present invention discloses a salt derivative of 1-(3-methanesulfonamidobenzyl)-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline shown in formula I. The salt derivative has a solubility in water of not less than 3.0 nmol/mL or 1.8 mg/mL.
(FR)La présente invention concerne un dérivé de sel de 1- (3-méthanesulfonamidobenzyl)-6-méthoxy-7-benzyloxy -1,2,3,4-tétrahydroisoquinoléine représenté par la formule I. Le dérivé de sel présente une solubilité dans l'eau qui n'est pas inférieure à 3,0 nmoles/mL ou 1,8 mg/mL.
(ZH)本发明公开了一种如式I所示的1-(3-甲磺酰胺基苄基)-6-甲氧基,7-苄氧基-1,2,3,4-四氢异喹啉的盐衍生物:所述盐衍生物在水中的溶解度不小于3.0nmol/mL或1.8mg/mL。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)