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1. (WO2018041004) ARYL-2,2'-TANDEM BISTHIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2018/041004    International Application No.:    PCT/CN2017/098883
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Fri Aug 25 01:59:59 CEST 2017
IPC: C07D 417/04
A61K 31/427
A61P 35/00
A61P 35/02
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
中国科学院上海药物研究所
Inventors: NAN, Fajun
南发俊
LI, Jia
李佳
DING, Jian
丁健
GENG, Meiyu
耿美玉
ZHANG, Yangming
张仰明
CHEN, Yi
陈奕
ZHOU, Yubo
周宇波
GONG, Chaojun
龚超骏
SU, Mingbo
苏明波
GAO, Anhui
高安慧
Title: ARYL-2,2'-TANDEM BISTHIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF
Abstract:
The present invention relates to an aryl-2,2'-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2'-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.