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1. (WO2018040407) EMBOLISM MATERIAL FOR BLOOD VESSEL, PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF DRUGS
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Pub. No.: WO/2018/040407 International Application No.: PCT/CN2016/111645
Publication Date: 08.03.2018 International Filing Date: 23.12.2016
IPC:
A61L 24/06 (2006.01) ,A61L 24/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24
Surgical adhesives or cements; Adhesives for colostomy devices
04
containing macromolecular materials
06
obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24
Surgical adhesives or cements; Adhesives for colostomy devices
Applicants:
安疗生命科学(武汉)有限公司 ANEW-MED LIFE SCIENCE (WUHAN) CO., LTD [CN/CN]; 中国湖北省武汉市 东湖新技术开发区高新大道666号武汉国家生物产业(九峰创新)基地B4栋1-5层 Layers 1-5 Wuhan National Biological Industry Base ( JiufengIinnovation) B4 layer 1-5, Gaoxin Road 666, East Lake High-Tech Development Zone, Wuhan, China WUhan, Hubei, CN
Inventors:
孙海霞 SUN, Haixia; CN
刘宏 LIU, Hong; CN
李涵 LI, Han; CN
曾坚 ZENG, Jian; CN
刘爽 LIU, Shuang; CN
卢欣 LU, Xin; CN
郭俊成 GUO, Juncheng; CN
袁冰寒 YUAN, Binghan; CN
李玲 LI, Ling; CN
Agent:
北京海虹嘉诚知识产权代理有限公司 HAIHONG JIACHENG INTELLECTUAL PROPERTY & PARTNERS; 中国北京市 海淀区海淀南路21号中关村知识产权大厦B座9层 9th Floor, Tower B, Zhongguancun Intellectual Property Mansion No.21, South Road Haidian, Haidian District, Beijing 100080 Beijing 100080, CN
Priority Data:
201610781459.931.08.2016CN
Title (EN) EMBOLISM MATERIAL FOR BLOOD VESSEL, PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF DRUGS
(FR) MATIÈRE D'EMBOLIE POUR VAISSEAU SANGUIN, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION DANS LA PRÉPARATION DE MÉDICAMENTS
(ZH) 一种血管栓塞材料、其制备方法及在药物制备中的用途
Abstract:
(EN) Provided are the use of poly(N-isopropyl acrylamide-co-butyl methacrylate) in preparing an embolism material for blood vessels, an embolism material for blood vessels and the use thereof in the preparation of drugs. The embolism material for blood vessels comprises poly(N-isopropyl acrylamide-co-butyl methacrylate) and a dispersion medium consisting of an electrolyte, a contrast agent, a pH regulator and water. The concentrations of the polymer, electrolyte and contrast agent are respectively 5-30 mg/ml, 0.1-30 mg/ml and 100-350 mg/ml based on iodine. The embolism material for blood vessels is suitable for the embolization therapy of tumors in hypervascular and parenchymal visceral organs.
(FR) L'invention porte sur l'utilisation du poly(N-isopropylacrylamide-co-butyl méthacrylate) dans la préparation d'une matière d'embolie pour vaisseaux sanguins, une matière d'embolie pour vaisseaux sanguins et son utilisation dans la préparation de médicaments. La matière d'embolie pour vaisseaux sanguins comprend du poly(N-isopropylacrylamide-co-butyl méthacrylate) et un milieu dispersé constitué d'un électrolyte, d'un révélateur, et d'un régulateur de pH et d'eau. Les concentrations du polymère de l'électrolyte et du révélateur sont respectivement de 5 à 30 mg/ml, de 0,1 à 30 mg/ml et de 100 à 350 mg/ml basé sur l'iode. La matière d'embolie pour vaisseaux sanguins est adéquate pour l'embolisation de tumeurs d'organes viscéraux hypervascularisés et parenchymateux.
(ZH) 聚(N-异丙基丙烯酰胺-co-甲基丙烯酸丁酯)在制备血管栓塞材料中的用途、一种血管栓塞材料及其在制备药物中的用途。血管栓塞材料包括聚(N-异丙基丙烯酰胺-co-甲基丙烯酸丁酯)和由电解质、显影剂、pH值调节剂和水组成分散介质,聚合物、电解质和显影剂以碘计,浓度分别为5~30mg/ml、0.1~30mg/ml及100~350mg/ml。适用于富血管性实质脏器肿瘤的栓塞治疗。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)