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1. (WO2018039972) INHIBITORS OF CELLULAR METABOLIC PROCESSES

Pub. No.:    WO/2018/039972    International Application No.:    PCT/CN2016/097524
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: C07D 401/04
A61K 31/519
A61P 35/00
Applicants: AGIOS PHARMACEUTICALS, INC.
TRAVINS, Jeremy, M.
KONTEATIS, Zenon, D.
SUI, Zhihua
YE, Zhixiong
Inventors: TRAVINS, Jeremy, M.
KONTEATIS, Zenon, D.
SUI, Zhihua
YE, Zhixiong
Title: INHIBITORS OF CELLULAR METABOLIC PROCESSES
Abstract:
The invention provides inhibitor compounds of MAT2A that are useful as therapeutic agents for treating malignancies wherein the compounds have the general formula (I) : wherein ring A, ring B, ring C and, R1 are as described herein.