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1. (WO2018039972) INHIBITORS OF CELLULAR METABOLIC PROCESSES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/039972    International Application No.:    PCT/CN2016/097524
Publication Date: 08.03.2018 International Filing Date: 31.08.2016
IPC:
C07D 401/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: AGIOS PHARMACEUTICALS, INC. [US/US]; 88 Sidney Street Cambridge, Massachusetts 02139 (US).
TRAVINS, Jeremy, M. [US/US]; (US) (US only).
KONTEATIS, Zenon, D. [US/US]; (US) (US only).
SUI, Zhihua [US/US]; (US) (US only).
YE, Zhixiong [US/CN]; (CN) (US only)
Inventors: TRAVINS, Jeremy, M.; (US).
KONTEATIS, Zenon, D.; (US).
SUI, Zhihua; (US).
YE, Zhixiong; (CN)
Agent: NTD PATENT & TRADEMARK AGENCY LIMITED; 10th Floor, Block A Investment Plaza, 27 Jinrongdajie Xicheng District Beijing 100033 (CN)
Priority Data:
Title (EN) INHIBITORS OF CELLULAR METABOLIC PROCESSES
(FR) INHIBITEURS DE PROCESSUS MÉTABOLIQUES CELLULAIRES
Abstract: front page image
(EN)The invention provides inhibitor compounds of MAT2A that are useful as therapeutic agents for treating malignancies wherein the compounds have the general formula (I) : wherein ring A, ring B, ring C and, R1 are as described herein.
(FR)L'invention concerne des composés inhibiteurs de MAT2A qui sont utiles en tant qu'agents thérapeutiques pour le traitement de malignités, les composés ayant la formule générale (I) : dans laquelle le cycle A, le cycle B, le cycle C et, R 1 sont tels que décrits ici.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)