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1. (WO2018039923) PREPARATION METHOD OF DIOSMIN

Pub. No.:    WO/2018/039923    International Application No.:    PCT/CN2016/097361
Publication Date: Fri Mar 09 00:59:59 CET 2018 International Filing Date: Wed Aug 31 01:59:59 CEST 2016
IPC: C07H 17/07
C07H 1/00
Applicants: CHENGDU OKAY PHARMACEUTICAL CO., LTD
成都欧康医药股份有限公司
Inventors: ZHAO, Zhuojun
赵卓君
Title: PREPARATION METHOD OF DIOSMIN
Abstract:
A preparation method of diosmin, comprising: A) mixing an amide solvent, hesperidin, an alkaline reagent, with iodine, and heating to react to obtain diosmin. Compared with the prior art, the amide solvent used as a reaction solvent has little toxicity, is easily soluble in water, and is easy to handle, thereby decreasing the amount of a solvent residue in a resulting product.