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1. (WO2018039810) PROVISION OF A THERAPEUTICALLY ACTIVE CELL PRODUCT
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Pub. No.: WO/2018/039810 International Application No.: PCT/CH2017/000080
Publication Date: 08.03.2018 International Filing Date: 29.08.2017
IPC:
C12N 5/0775 (2010.01) ,C12N 5/077 (2010.01) ,A61K 35/28 (2015.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
Applicants:
PDI PHARM DEVELOPMENT INTERNATIONAL AG [CH/CH]; Bahnhofstrasse 4 6052 Hergiswil, CH
Inventors:
ORLOWSKI, Wojciech; PL
Agent:
E. BLUM & CO. AG; Vorderberg 11 8044 Zürich, CH
Priority Data:
1109/1629.08.2016CH
Title (EN) PROVISION OF A THERAPEUTICALLY ACTIVE CELL PRODUCT
(FR) FOURNITURE D'UN PRODUIT CELLULAIRE THÉRAPEUTIQUEMENT ACTIF
Abstract:
(EN) A therapeutically active cell product and an ex vivo method for preparing it from a tissue donation are provided. The method comprises an in vitro immuno- depletion of hematopoietic stem cells and cells of hematopoietic lineage. The therapeutically active cell product obtained by the method comprises a portion of non-hematopoietic stem cells comprising non-hematopoietic progenitor [stem] cells, multipotent stem cells and/or pluripotent stem cells. Further aspects include the cell product for therapeutic use, in particular for the treatment of autoimmune and/or neurological disease.
(FR) L'invention concerne un produit cellulaire thérapeutiquement actif et un procédé ex vivo de préparation de ce dernier à partir d'un don de tissu. Le procédé comprend une immuno-déplétion in vitro de cellules souches hématopoïétiques et de cellules de lignée hématopoïétique. Le produit cellulaire thérapeutiquement actif obtenu au moyen du procédé comprend une partie de cellules souches non hématopoïétiques comprenant des cellules [souches] progénitrices non hématopoïétiques, des cellules souches multipotentes et/ou des cellules souches pluripotentes. D'autres aspects comprennent le produit cellulaire à usage thérapeutique, en particulier pour le traitement d'une maladie auto-immune et/ou neurologique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)