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1. (WO2018039755) ZINC- AND QUERCETIN-BASED PHARMACEUTICAL FORMULATION FOR THE PRODUCTION OF ANTIVIRAL MEDICATION EFFECTIVE FOR DENGUE AND ZIKA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2018/039755 International Application No.: PCT/BR2016/050220
Publication Date: 08.03.2018 International Filing Date: 05.09.2016
IPC:
A61K 31/353 (2006.01) ,A61K 33/30 (2006.01) ,A61P 31/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
30
Zinc; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
Applicants:
SAAD, William Abrão [BR/BR]; BR
PARK, Dong Hui [KR/BR]; BR
Inventors:
SAAD, William Abrão; BR
PARK, Dong Hui; BR
Agent:
BEERRE ASSESSORIA EMPRESARIAL LTDA; Av Barão de Itapura, 3236 Taquaral 13073-300 Campinas - SP, BR
Priority Data:
BR102016020391-002.09.2016BR
Title (EN) ZINC- AND QUERCETIN-BASED PHARMACEUTICAL FORMULATION FOR THE PRODUCTION OF ANTIVIRAL MEDICATION EFFECTIVE FOR DENGUE AND ZIKA
(FR) FORMULATION PHARMACEUTIQUE À BASE DE ZINC ET DE QUERCÉTINE POUR LA PRODUCTION D’UN MÉDICAMENT ANTIVIRAL EFFICACE CONTRE LA DENGUE ET ZIKA
(PT) FORMULAÇÃO FARMACÊUTICA A BASE DE ZINCO E QUERCETINA PARA A PRODUÇÃO DE MEDICAÇÃO ANTIVIRAL EFICAZ PARA DENGUE E ZIKA
Abstract:
(EN) The present invention relates to compositions for preventing or treating the symptoms of infections caused by Flavivirus, such as Dengue. The compositions comprise a combination of a zinc compound, which can be chelated and/or non-chelated with the flavonoid quercetin or analogues and derivatives thereof, with other components also being optionally included in the formulation according to the recommendation, age group, form of presentation, existing conditions and weight. Antiviral activity is achieved by means of the synergistic effect of quercetin and zinc, which act via various mechanisms of action, preventing the virus from creating mechanisms of resistance. The present invention falls within the field of pharmacy, notably where said compositions can be produced for HUMAN AND ANIMAL use in the following DOSAGE FORMS: ORAL in capsules, which can be hard, soft or gelatinous; tablets, which can be coated or uncoated, in the form of dragées, film-coated and also dispersible; syrups; solutions; suspensions; emulsions and gel solutions. INJECTABLES: ampoule, vial-ampoule, physiological and glucose saline. TOPICAL: ointment, cream, paste, powder and gel, and micro- and nanostructures can also be used. INHALATIONAL: spray and nebulizer.
(FR) La présente invention concerne des compositions pour prévenir ou traiter les symptômes infectieux causés par flavivirus, notamment la dengue. Ces compositions comprennent une combinaison d'un composé de zinc pouvant être chélaté et/ou non chélaté avec le flavonoïde quercétine ou ses analogues et dérivés, d’autres composants pouvant en outre entrer dans la formulation selon l'indication, la tranche d’âge, la forme de présentation, les pathologies existantes et le poids. L’activité antivirale est atteinte au moyen de l’effet synergique de la quercétine et du zinc, qui agissent à travers différents mécanismes d’action, empêchant que le virus développe des mécanismes de résistance. La présente invention relève du domaine de la pharmacie, et permet notamment une production en vue d’une utilisation chez l’homme et l’animal dans les formes pharmaceutiques suivantes : Forme orale en capsule : peut être dure, molle ou gélatineuse, comprimé : peut être enrobé ou non, dragéifié, filmé ou encore dispersible, sirops, solutions, suspensions, émulsions et solutions en gel. Formes injectables : ampoule, flacon-ampoule, sérum physiologique et glycosylé. Forme topique : pommade, crème, pâte, poudre et gel, des micro-structures et des nano-structures pouvant en outre être utilisées. Forme inhalatoire : spray et nébuliseur.
(PT) A presente invenção refere-se a composições para a prevenção ou tratamento dos sintomas de infecções causados por Flavivirus, como Dengue. As composições compreendem uma combinação de composto de zinco, podendo ser quelado e/ou não-quelado com o flavonoide quercetina ou seus análogos e derivados, podendo ainda outros componentes entrarem na formulação de acordo com a indicação, faixa etária, forma de apresentação, patologias existentes e peso. A atividade antiviral é alcançada por meio do efeito sinérgico da quercetina e do zinco que atuam através de diferentes mecanismos de ação, impedindo que o vírus crie mecanismos de resistência. A presente Invenção situa-se no campo da farmácia, notadamente onde poderão ser produzidos para uso HUMANO E ANIMAL nas seguintes FORMAS FARMACÊUTICAS: ORAL em Cápsulas: podendo ser dura, mole ou gelatinosa, comprimidos: podendo ser revestido ou não, drageados, filmados e ainda dispersivos, Xaropes, Soluções, Suspensões, Emulsões e Soluções em gel. INJETÁVEIS: Ampola, Frasco-ampola, soro fisiológico e glicosado. TÓPICA: pomada, creme, Pasta, Pó e Gel e ainda pode ser utilizado micro e nano estruturas. INALATÓRIO: Spray e nebulizador.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Portuguese (PT)
Filing Language: Portuguese (PT)