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1. (WO2018039752) DRY ENTERIC NITROSATION COMPOSITION AND USE
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Pub. No.: WO/2018/039752 International Application No.: PCT/BR2016/000154
Publication Date: 08.03.2018 International Filing Date: 21.12.2016
IPC:
C01B 21/36 (2006.01) ,C07C 321/04 (2006.01) ,A61K 31/04 (2006.01) ,A61K 31/095 (2006.01) ,A61K 31/197 (2006.01) ,A61K 31/198 (2006.01) ,A61K 47/38 (2006.01) ,A61P 1/04 (2006.01) ,A61P 1/16 (2006.01)
C CHEMISTRY; METALLURGY
01
INORGANIC CHEMISTRY
B
NON-METALLIC ELEMENTS; COMPOUNDS THEREOF
21
Nitrogen; Compounds thereof
20
Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
36
Nitrogen dioxide (NO2, N2O4)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
321
Thiols, sulfides, hydropolysulfides or polysulfides
02
Thiols having mercapto groups bound to acyclic carbon atoms
04
of an acyclic saturated carbon skeleton
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
04
Nitro compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
095
Sulfur, selenium or tellurium compounds, e.g. thiols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
04
for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants:
UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP [BR/BR]; Rua Roxo Moreira 1831 - Cidade Universitária "Zeferino Vaz" - Distrito de Barão Geraldo Caixa Postal 6.131 CEP: 13083-970 Campinas - SP, BR
Inventors:
DE OLIVEIRA, Marcelo Ganzarolli; BR
DE SOUZA, Gabriela Freitas Pereira; BR
Agent:
SILVADO, Fernanda Lavras Costallat; Rua Roxo Moreira, 1831 - Cidade Universitaria "Zeferino Vaz" Distrito de Barão Geraldo Caixa Postal 6.131 CEP: 13083-970 - Campinas - SP, BR
Priority Data:
BR 10 2016 020040 730.08.2016BR
Title (EN) DRY ENTERIC NITROSATION COMPOSITION AND USE
(FR) COMPOSITION SÈCHE DE NITROSATION ENTÉRIQUE ET SON UTILISATION
(PT) COMPOSIÇÃO SECA DE NITROSAÇÃO ENTÉRICA E USO
Abstract:
(EN) The present invention relates to a dry composition comprising a solid thiol precursor and solid sodium nitrite (NaNO2) incorporated in dry, solid hydrophilic polymer matrices for inducing therein a nitrosation reaction of the thiol precursor following the absorption of water from the gastrointestinal environment. The present invention falls within the field of application of medical-pharmaceutical sciences, more specifically of medicinal preparations characterized by special physical forms.
(FR) La présente invention concerne une composition sèche comprenant un thiol précurseur et du nitrite de sodium (NaNO2) solides incorporés dans des matrices polymères hydrophiles solides et sèches pour favoriser intérieurement la réaction de nitrosation du thio précurseur à partir de l'absorption d'eau en provenance du milieu gastro-intestinal. La présente invention relève du domaine d'application des sciences médico-pharmaceutiques, et notamment des préparations médicales caractérisées par des formes physiques spéciales.
(PT) A presente invenção se refere a uma composição seca que compreende um tiol precursor e nitrito de sódio (NaNO2) sólidos incorporados em matrizes poliméricas hidrofílicas sólidas e secas para promover em seu interior a reação de nitrosação do tiol precursor a partir da absorção de agua proveniente do meio gastrointestinal. A presente invenção se insere no campo de aplicação das ciências médico-farmacêuticas, mais especificamente, das preparações medicinais caracterizadas por formas físicas especíais.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Portuguese (PT)
Filing Language: Portuguese (PT)